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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Delivering nitric oxide into human skin from encapsulated S-nitrosoglutathione under UV light: An in vitro and ex vivo study

Full text
Author(s):
Pelegrino, Milena T. [1] ; Weller, Richard B. [2] ; Paganotti, Andre [3] ; Seabra, Amedea B. [1]
Total Authors: 4
Affiliation:
[1] Univ Fed ABC, Ctr Nat & Human Sci, Santo Andre, SP - Brazil
[2] Univ Edinburgh, Queens Med Res Inst, Med Res Council Ctr Inflammat Res, Edinburgh, Midlothian - Scotland
[3] Univ Fed Sao Paulo, Lab Mat & Mech Manufacture, Diadema - Brazil
Total Affiliations: 3
Document type: Journal article
Source: NITRIC OXIDE-BIOLOGY AND CHEMISTRY; v. 94, p. 108-113, JAN 1 2020.
Web of Science Citations: 0
Abstract

Nitric oxide (NO) is a crucial molecule in the human body. The encapsulation of exogenous NO donors into chitosan nanoparticles (CS NPs) has been widely used to overcome NO drawbacks in pharmacological applications, such as, its short half-life. The NO donor, S-nitrosoglutathione (GSNO), was encapsulated into CS NPs (GSNO-CS NPs) and characterized by AFM and DLS measurements. The nanoparticles presented a hydrodynamic size of 123.3 +/- 1.5 nm and a polydispersity of 0.25 +/- 0.01. The ability of GSNO-CS NPs, combined with UV irradiation, to deliver NO was evaluated using ex vivo human skin. The human skin was pre-treated with GSNO-CS NPs, in the presence and absence of UV irradiation. The results showed that the combined treatment significantly increased the NO and S-nitrosothiol levels in human skin. This effect can emulate the cardiovascular benefits related to NO without negative side effects of skin exposure to UV light. (AU)

FAPESP's process: 18/08194-2 - Essential oil amended with metal nanoparticles functionalized with nitric oxide as a strategy to control plant pathogens in the agriculture
Grantee:Amedea Barozzi Seabra
Support Opportunities: Regular Research Grants
FAPESP's process: 17/05029-8 - Preparation, characterization and biological evaluation of nitric oxide releasing polymeric biomaterials
Grantee:Milena Trevisan Pelegrino
Support Opportunities: Scholarships in Brazil - Doctorate