Synthesis, Characterization, and Cytotoxicity of Fe3O4@Ag Hybrid Nanoparticles: Promising Applications in Cancer Treatment

Author(s)

Pieretti, Joana C. ^[1] ; Rolim, Wallace R. ^[1] ; Ferreira, Fabio F. ^{[2, 1, 3]} ; Lombello, Christiane B. ^{[2, 3]} ; Nascimento, Monica H. M. ^[1] ; Seabra, Amedea B. ^{[2, 1]}

Affiliation

^[1] Fed Univ ABC UFABC, Ctr Nat & Human Sci CCNH, Ave Estados 5001, BR-09210580 Santo Andre, SP - Brazil

^[2] Fed Univ ABC UFABC, Nanomed Res Unit NANOMED, BR-09210580 Santo Andre, SP - Brazil

^[3] Fed Univ ABC UFABC, Ctr Engn Modeling & Appl Social Sci CECS, BR-09210580 Santo Andre, SP - Brazil

• Document type: Journal article
• Source: JOURNAL OF CLUSTER SCIENCE; v. 31, n. 2, p. 535-547, MAR 2020.
• Web of Science Citations: 0

Abstract

Hybrid nanomaterials have been extensively investigated because of the possibility of obtaining multiple functions in one stable entity. The magnetite nanoparticles (Fe3O4 NPs) present unique superparamagnetic properties that enable their application in various fields. Silver nanoparticles (Ag NPs) also stand out in biomedical applications, especially as antitumorigenic and antibacterial agent. The combination of Fe3O4 NPs and Ag NPs in one hybrid nanostructure (Fe3O4@Ag NPs) represents a promising strategy for targeted biomedical applications. Fe3O4@Ag NPs can be synthesized through a green route using natural reagents, as both reducing and capping agent, minimizing the nanomaterial toxicity. In this work, Fe3O4@Ag NPs were synthesized via a green route, and green tea extract was used as the reducing agent of silver ions and capping agent of the obtained Fe3O4@Ag NPs. The nanoparticles were characterized by several techniques confirming the formation of a hybrid composite consisting of 87.1% of Fe3O4 and 12.9% of Ag, with spherical shape and an average size of 25 nm. The cytotoxicity of Fe3O4@Ag NPs was verified against both tumoral and non-tumoral cell lines, demonstrating selective cytotoxicity against tumoral cell line, suggesting a biocompatibility of these nanoparticles. Thus, superparamagnetic hybrid Fe3O4@Ag NPs might find important biomedical applications with targeted antitumorigenic properties. Graphic (AU)

• FAPESP's process: 18/08194-2 - Essential oil amended with metal nanoparticles functionalized with nitric oxide as a strategy to control plant pathogens in the agriculture
• Grantee: Amedea Barozzi Seabra
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/02832-7 - Hybrid magnetic and antibacterial nanoparticles: synthesis, characterization and applications
• Grantee: Joana Claudio Pieretti
• Support Opportunities: Scholarships in Brazil - Master