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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Impact of green tea epigallocatechin-3-gallate on HIF1-α and mTORC2 expressionin obese women: anti-cancer and anti-obesity effects?

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Author(s):
C. F. Nicoletti [1] ; H. B. P. Delfino [2] ; M. A. S. Pinhel [3] ; N. Y. Noronha [4] ; V. C. Pinhanelli [5] ; D. C. G. Quinhoneiro [6] ; B. A. P. Oliveira [7] ; J. S. Marchini [8] ; C. B. Nonino [9]
Total Authors: 9
Affiliation:
[1] Ribeirao Preto Medical School. University of São Paulo. Department of Internal Medicine - Brasil
[2] Ribeirao Preto Medical School. University of São Paulo. Department of Internal Medicine - Brasil
[3] Ribeirao Preto Medical School. University of São Paulo. Department of Internal Medicine - Brasil
[4] Ribeirao Preto Medical School. University of São Paulo. Department of Internal Medicine - Brasil
[5] Ribeirao Preto Medical School. University of São Paulo. Department of Internal Medicine - Brasil
[6] Ribeirao Preto Medical School. University of São Paulo. Department of Internal Medicine - Brasil
[7] Ribeirao Preto Medical School. University of São Paulo. Department of Internal Medicine - Brasil
[8] Ribeirao Preto Medical School. University of São Paulo. Department of Internal Medicine - Brasil
[9] Ribeirao Preto Medical School. University of São Paulo. Department of Internal Medicine - Brasil
Total Affiliations: 9
Document type: Journal article
Source: NUTRICION HOSPITALARIA; v. 36, n. 2, p. 315-320, 2020-01-20.
Abstract

Abstract Introduction: epigallocatechin-3-gallate (EGCG) is the most abundant catechin contained in green tea (Camellia sinensis) and has been associated with anti-obesity and anti-cancer effects, but the exact molecular mechanisms remain elusive. In this context, this study was designed to improve the understanding of the EGCG anti-obesity and anti-cancer action. Objectives: this study was designed to examine the effects of EGCG on the expression of genes involved in obesity and cancer pathways in the peripheral blood mononuclear cells of obese women. Material and methods: this longitudinal interventional study enrolled eleven women with severe obesity that were submitted to eight weeks of green tea (decaffeinated green tea capsules with 450.7 mg of EGCG, two capsules/day) supplementation (intervention group) and ten eutrophic women as a control group. Weight (kg), body mass index (BMI, kg/m2), fat mass (kg) and gene expression (qPCR method) were assessed before and after supplementation. HIF1-alpha (HIF1-α), phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) and rapamycin-insensitive companion of mTOR (RICTOR) were selected as potential targets. Results: after supplementation, body weight (114.9 ± 14.3 versus 115 ± 13.8 kg), body mass index (44.1 ± 3.7 versus 44.1 ± 3.9 kg/m2) and fat mass (47.6 ± 3.3 versus 47.3 ± 3.4 kg) did not change. EGCG upregulated the RICTOR and HIF1-α expression, however, did not modify PI3K expression. Conclusion: this study demonstrated that EGCG has a potential role to obesity and cancer related to obesity control and can be used not only for the purpose of weight loss, but also for the improvement of obesity-related comorbidities. (AU)

FAPESP's process: 13/08916-4 - Analysis of the expression of genes related to energy expenditure and lipid metabolism in individuals with grade III obesity before and after interventions for weight loss
Grantee:Carla Barbosa Nonino
Support Opportunities: Regular Research Grants