Effect of green tea extract rich in epigallocatechin-3-gallate on hepatic metabolic biomarkers in mice treated with high fat diet

• Grant number: 14/19508-7
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2015
• End date: February 28, 2017
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Lila Missae Oyama
• Grantee: Lila Missae Oyama
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated researchers: Claudia Maria da Penha Oller do Nascimento ; Fábio Santos de Lira

Abstract

The increase of body weight gain observed in the lasts decades pointed the obesity as a public health problem. The genese of the obesity is multifactorial, among others factors involving the intake of diet enriched with saturated fat acid. The obesity is associated with metabolic disease like a hepatic non alcoholic disease. It is enhanced the importance of alternative therapeutic methods to combat or prevent the obesity and associated diseases. Several studies have demonstrated the beneficial effects of phenolic compounds present in green tea, mainly epigallocatechin-3-gallate, positively acting on changes observed in metabolic diseases. However there are few studies that elucidate the possible effects of these bioactive compounds on metabolic biomarkers. One possibility is through the reduction on lipogenesis de novo and also by activating AMPK/LKB1 increasing the fatty acids oxidation process in liver. Therefore, the aim of this study is to investigate the metabolic effects of the consumption of green tea extract rich in epigallocatechin-3-gallate in liver of mice fed with high fat diet. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LOSINSKAS HACHUL, ANA CLAUDIA; BOLDARINE, VALTER TADEU; PINTO NETO, NELSON INACIO; MORENO, MAYARA FRANZOI; CARVALHO, PATRICIA OLIVEIRA; SAWAYA, ALEXANDRA C. H. F.; RIBEIRO, ELIANE BERALDI; OILER DO NASCIMENTO, CLAUDIA MARIA; OYAMA, LILA MISSAE. Effect of the consumption of green tea extract during pregnancy and lactation on metabolism of mothers and 28d-old offspring. SCIENTIFIC REPORTS, v. 8, JAN 30 2018. (14/19508-7)

SANTAMARINA, ALINE B.; CARVALHO-SILVA, MILENA; GOMES, LARA M.; OKUDA, MARCOS H.; SANTANA, ALINE A.; STRECK, EMILIO L.; SEELAENDER, MARILIA; OLLER DO NASCIMENTO, CLAUDIA M.; RIBEIRO, ELIANE B.; LIRA, FABIO S.; et al. Decaffeinated green tea extract rich in epigallocatechin-3-gallate prevents fatty liver disease by increased activities of mitochondrial respiratory chain complexes in diet-induced obesity mice. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v. 26, n. 11, p. 1348-1356, NOV 2015. (14/19508-7)

SANTAMARINA, ALINE B.; OLIVEIRA, JULIANA L.; SILVA, FERNANDA P.; CARNIER, JUNE; MENNITTI, LAIS V.; SANTANA, ALINE A.; DE SOUZA, GABRIEL H. I.; RIBEIRO, ELIANE B.; OLLER DO NASCIMENTO, CLAUDIA M.; LIRA, FABIO S.; et al. Green Tea Extract Rich in Epigallocatechin-3-Gallate Prevents Fatty Liver by AMPK Activation via LKB1 in Mice Fed a High-Fat Diet. PLoS One, v. 10, n. 11, NOV 4 2015. (14/19508-7)

HACHUL, ANA C. L.; BOLDARINE, VALTER T.; NETO, NELSON I. P.; MORENO, MAYARA F.; RIBEIRO, ELIANE B.; DO NASCIMENTO, CLAUDIA M. O.; OYAMA, LILA M.. Maternal consumption of green tea extract during pregnancy and lactation alters offspring's metabolism in rats. PLoS One, v. 13, n. 7, JUL 18 2018. (14/19508-7)