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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Inflammatory markers in the hippocampus after audiogenic kindling

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Author(s):
de Deus, Junia Lara [1] ; Amorim, Mateus Ramos [2] ; Gama de Barcellos Filho, Procopio Cleber [1] ; Cortes de Oliveira, Jose Antonio [1] ; Batalhao, Marcelo Eduardo [3] ; Garcia-Cairasco, Norberto [1] ; Carnio, Evelin Capellari [3] ; Leao, Ricardo Mauricio [1] ; de Siqueira Branco, Luiz Guilherme [2] ; Siqueira Cunha, Alexandra Olimpio [1]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Physiol, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Morphol Physiol & Basic Pathol, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Sch Nursing Ribeirao Preto, Dept Gen & Specialized Nursing, Ribeirao Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Neuroscience Letters; v. 721, MAR 16 2020.
Web of Science Citations: 0
Abstract

Here, we investigated the participation of pro and anti-inflammatory cytokines in the spread of repeated audiogenic seizures from brainstem auditory structures to limbic areas, including the hippocampus. We used Wistar Audiogenic Rats (WARS) and Wistars submitted to the audiogenic kindling protocol with a loud broad-band noise. We measured pro and anti-inflammatory cytokines and nitrate levels in the hippocampus of stimulated animals. Our results show that all WARS developed audiogenic seizures that evolved to limbic seizures whereas seizure-resistant controls did not present any seizures. However, regardless of seizure severity, we did not observe differences in the pro inflammatory cytokines IL-1 beta, IL-6, TNF-alpha and IFN-alpha or in the anti-inflammatory IL-10 in the hippocampi of audiogenic and resistant animals. We also did not find any differences in nitrate content. Our data indicate that the spread of seizures during the audiogenic kindling is not dependent on hippocampal release of cytokines or oxidative stress, but the severity of brainstem seizures will be higher in animals with higher levels of cytokines and the oxidative stress marker, nitrate. (AU)

FAPESP's process: 17/09878-0 - Effect of vagal stimulation during LPS immune challenge in normotensive and spontaneously hypertensive rats
Grantee:Mateus Ramos Amorim
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 15/22327-7 - Analysis of electrophysiological and morphofunctional properties of neurons in the central nucleus of inferior colliculus related to genesis and spreading of sound-induced convulsive seizures
Grantee:Alexandra Olimpio Siqueira Cunha
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 16/01607-4 - High intensity sound stimulation and synaptic plasticity
Grantee:Ricardo Mauricio Xavier Leão
Support Opportunities: Regular Research Grants
FAPESP's process: 16/17681-9 - Pathophysiological changes during systemic inflammation
Grantee:Luiz Guilherme de Siqueira Branco
Support Opportunities: Research Projects - Thematic Grants