| Full text | |
| Author(s): |
de Deus, Junia Lara
[1]
;
Amorim, Mateus Ramos
[2]
;
Gama de Barcellos Filho, Procopio Cleber
[1]
;
Cortes de Oliveira, Jose Antonio
[1]
;
Batalhao, Marcelo Eduardo
[3]
;
Garcia-Cairasco, Norberto
[1]
;
Carnio, Evelin Capellari
[3]
;
Leao, Ricardo Mauricio
[1]
;
de Siqueira Branco, Luiz Guilherme
[2]
;
Siqueira Cunha, Alexandra Olimpio
[1]
Total Authors: 10
|
| Affiliation: | [1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Physiol, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Morphol Physiol & Basic Pathol, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Sch Nursing Ribeirao Preto, Dept Gen & Specialized Nursing, Ribeirao Preto, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Neuroscience Letters; v. 721, MAR 16 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Here, we investigated the participation of pro and anti-inflammatory cytokines in the spread of repeated audiogenic seizures from brainstem auditory structures to limbic areas, including the hippocampus. We used Wistar Audiogenic Rats (WARS) and Wistars submitted to the audiogenic kindling protocol with a loud broad-band noise. We measured pro and anti-inflammatory cytokines and nitrate levels in the hippocampus of stimulated animals. Our results show that all WARS developed audiogenic seizures that evolved to limbic seizures whereas seizure-resistant controls did not present any seizures. However, regardless of seizure severity, we did not observe differences in the pro inflammatory cytokines IL-1 beta, IL-6, TNF-alpha and IFN-alpha or in the anti-inflammatory IL-10 in the hippocampi of audiogenic and resistant animals. We also did not find any differences in nitrate content. Our data indicate that the spread of seizures during the audiogenic kindling is not dependent on hippocampal release of cytokines or oxidative stress, but the severity of brainstem seizures will be higher in animals with higher levels of cytokines and the oxidative stress marker, nitrate. (AU) | |
| FAPESP's process: | 17/09878-0 - Effect of vagal stimulation during LPS immune challenge in normotensive and spontaneously hypertensive rats |
| Grantee: | Mateus Ramos Amorim |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 15/22327-7 - Analysis of electrophysiological and morphofunctional properties of neurons in the central nucleus of inferior colliculus related to genesis and spreading of sound-induced convulsive seizures |
| Grantee: | Alexandra Olimpio Siqueira Cunha |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 07/50261-4 - Neurociências, epilepsia e arte: caracterização interdisciplinar da cepa WAR e modelos de epilepsia correlacionados: as oficinas Da Vinci, divulgação científica e quebras de estigmas em epilepsia |
| Grantee: | Norberto Garcia Cairasco |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 16/01607-4 - High intensity sound stimulation and synaptic plasticity |
| Grantee: | Ricardo Mauricio Xavier Leão |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 16/17681-9 - Pathophysiological changes during systemic inflammation |
| Grantee: | Luiz Guilherme de Siqueira Branco |
| Support Opportunities: | Research Projects - Thematic Grants |