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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Bidens pilosa (Black Jack) Standardized Extract Ameliorates Acute TNBS-induced Intestinal Inflammation in Rats

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Author(s):
Quaglio, V, Ana E. ; Cruz, Vinicius M. [1] ; Almeida-Junior, Luiz D. [1] ; Costa, Celso A. R. A. [1] ; Di Stasi, Luiz C. [1]
Total Authors: 5
Affiliation:
[1] Quaglio, Ana E., V, Sao Paulo State Univ, Lab Phytomed Pharmacol & Biotechnol PhytoPharmaTe, Dept Pharmacol, UNESP, Inst Biosci, Rua Prof Dr Antonio Celso Wagner Zanin 250, BR-18618689 Botucatu, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Planta Medica; v. 86, n. 5, p. 319-330, MAR 2020.
Web of Science Citations: 0
Abstract

Bidens pilosa is an herb popularly used to treat inflammation, hemorrhoids, fever, and gastric ulcers with reported pharmacological activities and chemical composition that sustain its selection as a potential intestinal anti-inflammatory product. Based on this, we examined the effects of a B. pilosa fatty acid-standardized supercritical preparation on the intestinal inflammatory process induced by trinitrobenzenesulphonic acid in rats, using either preventative or curative treatments. We also investigated the safety of plant extract by acute and sub-chronic toxicological analysis. The intestinal anti-inflammatory activity was related to modulation of the immune response, increasing IL-10 production and reducing IL-1 beta , IL-6, and TNF- alpha level, the oxidative stress, and the MUC production in the inflamed colon. Optic, scanning, and transmission electron microscopy (TEM) analysis supported the beneficial effects promoted by B. pilosa , which were closely related to downregulation of heparanase, Hsp70, Mapk 3, and NF- kappa B signaling and with the presence of long-chain fatty acids in extract. Our data suggest that B. pilosa supercritical preparation is a chemically standardized preparation potentially useful as complementary intestinal anti-inflammatory agent to treat inflammatory bowel disease. (AU)

FAPESP's process: 17/03959-8 - MicroRNAs as diagnosis and prognosis markers of ulcerative colitis and Crohn's disease in patients with inflammatory bowel disease
Grantee:Ana Elisa Valencise Quaglio
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 15/15267-8 - Inflammatory bowel disease (IBD): novel approaches for diagnosis and gut microbiota modulation in ulcerative colitis patients
Grantee:Luiz Claudio Di Stasi
Support Opportunities: Research Projects - Thematic Grants