Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Role of extracellular vesicles during oocyte maturation and early embryo development

Full text
de Avila, A. C. F. C. M. [1] ; da Silveira, J. C. [1]
Total Authors: 2
[1] Univ Sao Paulo, Fac Anim Sci & Food Engn, Dept Vet Med, Ave Duque Caxias Norte 225, Pirassununga 13635900, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: REPRODUCTION FERTILITY AND DEVELOPMENT; v. 32, n. 1-2, p. 56-64, 2020.
Web of Science Citations: 1

The follicle is a dynamic microenvironment in the ovary where the oocyte develops. Intercellular communication between somatic cells and the oocyte inside the follicle is essential to generate a competent gamete. Extracellular vesicles are nanoparticles secreted by cells that mediate cell-to-cell communication in the follicle microenvironment and can be obtained from the follicular fluid. These extracellular vesicles have been studied as biomarkers and supplementation tools to mimic physiological conditions during assisted reproductive techniques because they are vehicles of bioactive molecules. Therefore, this paper reviews the importance of changes in the ovarian follicle and the effects of extracellular vesicles from follicular fluid during oocyte maturation and early embryo development. Finally, we propose that is important to consider the source of the extracellular vesicles to improve diagnostic methods and to increase in vitro embryo production. (AU)

FAPESP's process: 17/02037-0 - Description of a new mechanism involved in cellular communication between female reproductive system cells and oocyte mediated by extracellular vesicles and their impacts on oocyte maturation, fertilization and bovine embryo cleavage
Grantee:Ana Clara Faquineli Cavalcante Mendes de Ávila
Support type: Scholarships in Brazil - Master
FAPESP's process: 14/22887-0 - Cell-secreted vesicles containing miRNAs modulate epigenetic changes during in vitro culture of bovine gametes and embryos
Grantee:Juliano Coelho da Silveira
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 15/21829-9 - Multi-user equipment approved in grant 2014/22887-0: Nanosight LM10
Grantee:Juliano Coelho da Silveira
Support type: Multi-user Equipment Program