Differential cytokine network profile in polycythemia vera and secondary polycythemia

Author(s):Show less -

Cacemiro, Maira da Costa ^[1] ; Cominal, Jucara Gastaldi ^[1] ; Berzoti-Coelho, Maria Gabriela ^[1] ; Tognon, Raquel ^[2] ; Nunes, Natalia de Souza ^[1] ; Simoes, Belinda ^[3] ; Pereira, Italo Sousa ^[4] ; Carlos, Daniela ^[4] ; Faccioli, Lucia Helena ^[1] ; de Figueiredo-Pontes, Lorena Lobo ^[3] ; Frantz, Fabiani Gai ^[1] ; de Castro, Fabiola Attie ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Anal Toxicol & Food Sci, Ribeirao Preto, SP - Brazil

^[2] Univ Fed Juiz de Fora, Dept Pharm, Campus Governador Valadares, Governador Valadares, MG - Brazil

^[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Med Images Hematol & Oncol, Ribeirao Preto, SP - Brazil

^[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Basic & Appl Immunol, Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: SCIENTIFIC REPORTS; v. 10, n. 1 APR 27 2020.
• Web of Science Citations: 0

Abstract

Polycythemia vera (PV) is a clonal disorder resulting from neoplastic transformation of hematopoietic stem cells, while secondary polycythemia (SP) is a disease characterized by increased absolute red blood cell mass caused by stimulation of red blood cell production. Although the physiopathology of SP and PV is distinct, patients with these diseases share similar symptoms. The early differential diagnosis may improve the quality of life and decrease the disease burden in PV patients, as well as enable curative treatment for SP patients. PV is considered an oncoinflammatory disease because PV patients exhibit augmented levels of several pro-inflammatory cytokines. In this sense, we examined whether analysis of the cytokine production profile of SP and PV patients would help to distinguish them, despite their clinical similarities. Here we reported that SP patients exhibited decreased plasma levels of, IL-17A, IFN-gamma, IL-12p70 and TNF-alpha when compared with PV patients, suggesting that analysis of the cytokine production profile may be an useful diagnostic biomarker to distinguish PV from SP patients. (AU)

• FAPESP's process: 15/23555-3 - Regulators microRNAs of HIPPO pathway in Chronic Myeloid Leukemia
• Grantee: Maria Gabriela Berzoti Coelho
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 17/23501-6 - CDR1as' role in tumorigenesis and metastasis of melanoma by miR-7 regulation
• Grantee: Maria Gabriela Berzoti Coelho
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 18/01756-5 - Immunological and Functional Characterization of Multipotent Mesenchymal Stromal Cells in Myeloproliferative Neoplasms
• Grantee: Maira da Costa Cacemiro
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 14/50947-7 - INCT 2014: in Stem Cell and Cell Therapy
• Grantee: Dimas Tadeu Covas
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 18/19714-7 - Bone Marrow Mesenchymal Stromal Cells deregulation effect on BCR-ABL1-Myeloproliferative Neoplasms pathophysiology and progression
• Grantee: Fabíola Attié de Castro
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/08135-2 - CTC - Center for Cell-Based Therapy
• Grantee: Dimas Tadeu Covas
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC