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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Differential cytokine network profile in polycythemia vera and secondary polycythemia

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Author(s):
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Cacemiro, Maira da Costa [1] ; Cominal, Jucara Gastaldi [1] ; Berzoti-Coelho, Maria Gabriela [1] ; Tognon, Raquel [2] ; Nunes, Natalia de Souza [1] ; Simoes, Belinda [3] ; Pereira, Italo Sousa [4] ; Carlos, Daniela [4] ; Faccioli, Lucia Helena [1] ; de Figueiredo-Pontes, Lorena Lobo [3] ; Frantz, Fabiani Gai [1] ; de Castro, Fabiola Attie [1]
Total Authors: 12
Affiliation:
[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Anal Toxicol & Food Sci, Ribeirao Preto, SP - Brazil
[2] Univ Fed Juiz de Fora, Dept Pharm, Campus Governador Valadares, Governador Valadares, MG - Brazil
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Med Images Hematol & Oncol, Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Basic & Appl Immunol, Ribeirao Preto, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 10, n. 1 APR 27 2020.
Web of Science Citations: 0
Abstract

Polycythemia vera (PV) is a clonal disorder resulting from neoplastic transformation of hematopoietic stem cells, while secondary polycythemia (SP) is a disease characterized by increased absolute red blood cell mass caused by stimulation of red blood cell production. Although the physiopathology of SP and PV is distinct, patients with these diseases share similar symptoms. The early differential diagnosis may improve the quality of life and decrease the disease burden in PV patients, as well as enable curative treatment for SP patients. PV is considered an oncoinflammatory disease because PV patients exhibit augmented levels of several pro-inflammatory cytokines. In this sense, we examined whether analysis of the cytokine production profile of SP and PV patients would help to distinguish them, despite their clinical similarities. Here we reported that SP patients exhibited decreased plasma levels of, IL-17A, IFN-gamma, IL-12p70 and TNF-alpha when compared with PV patients, suggesting that analysis of the cytokine production profile may be an useful diagnostic biomarker to distinguish PV from SP patients. (AU)

FAPESP's process: 15/23555-3 - Regulators microRNAs of HIPPO pathway in Chronic Myeloid Leukemia
Grantee:Maria Gabriela Berzoti Coelho
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/23501-6 - CDR1as' role in tumorigenesis and metastasis of melanoma by miR-7 regulation
Grantee:Maria Gabriela Berzoti Coelho
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 18/01756-5 - Immunological and Functional Characterization of Multipotent Mesenchymal Stromal Cells in Myeloproliferative Neoplasms
Grantee:Maira da Costa Cacemiro
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/50947-7 - INCT 2014: in Stem Cell and Cell Therapy
Grantee:Dimas Tadeu Covas
Support type: Research Projects - Thematic Grants
FAPESP's process: 18/19714-7 - Bone Marrow Mesenchymal Stromal Cells deregulation effect on BCR-ABL1-Myeloproliferative Neoplasms pathophysiology and progression
Grantee:Fabíola Attié de Castro
Support type: Regular Research Grants
FAPESP's process: 13/08135-2 - CTC - Center for Cell-Based Therapy
Grantee:Dimas Tadeu Covas
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC