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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Partial remission in Brazilian children and adolescents with type 1 diabetes. Association with a haplotype of class II human leukocyte antigen and synthesis of autoantibodies

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Camilo, Daniela S. [1] ; Pradella, Fernando [1] ; Paulino, Maria Fernanda [2] ; Baracat, Emilio C. E. [2] ; Marini, Sofia H. [2] ; Guerra, Jr., Gil [2] ; Pavin, Elizabeth J. [3] ; Parisi, Candida [3] ; Longhini, Ana Leda F. [1] ; Marques, Silvia B. [4] ; Guariento, Edilaine G. [4] ; Lieber, Sofia R. [4] ; Macedo, Carlos Fernando [1] ; Gama e Silva, Leticia [1] ; Farias, Alessandro S. [1, 5] ; Santos, Leonilda M. B. [1, 5] ; Volpini, Walkyria M. G. [1]
Total Authors: 17
Affiliation:
[1] Campinas Univ UNICAMP, Inst Biol, Neuroimmunol Unit, Campinas - Brazil
[2] Campinas Univ UNICAMP, Dept Pediat, Campinas - Brazil
[3] Campinas Univ UNICAMP, Endocrinol Diabet Serv, Clin Hosp, Campinas - Brazil
[4] Campinas Univ UNICAMP, Blood Ctr, HLA Lab, Campinas - Brazil
[5] CNPq, Natl Inst Sci & Technol Neuroimmunomodulat INCT N, Brasilia, DF - Brazil
Total Affiliations: 5
Document type: Journal article
Source: PEDIATRIC DIABETES; v. 21, n. 4, p. 606-614, JUN 2020.
Web of Science Citations: 0
Abstract

Objective Characterization of partial remission using the insulin dose-adjusted HbA1c (IDAA1c) <= 9 definition in a multiethnic Brazilian population of children and adolescents with type 1 diabetes (T1D), in addition with the determination of both Class II HLA genotype and autoantibodies. Methods We analyzed the prevalence of partial remission in 51 new-onset T1D patients with a median time follow-up of 13 months from diagnosis. For this study, anti-GAD65, anti-IA2 and HLA class II genotyping were considered. Results Partial remission occurred in 41.2% of T1D patients until 3 months after diagnosis, mainly in those aged 5-15 years. We have demonstrated a significant increase in the haplotypes of class II HLA DRB1{*}0301-DQB1{*}0201 in children and adolescents with a partial remission phase of the disease (42.9% vs 21.7% in non-remitters, P = .0291). This haplotype was also associated with the reduction of anti-IA2 antibodies production. Homozygote DRB1{*}03-DQB1{*}0201/DRB1{*}03-DQB1{*}0201 children had the lowest prevalence of IA-2A antibodies (P = .0402). However, this association does not correlate with the time of the remission phase. Conclusion Although the number of patients studied was reduced, our data suggested that the association between genetics and decrease in antibody production to certain islet auto-antigen may contribute, at least in part, to the remission phase of T1D. (AU)

FAPESP's process: 12/24667-1 - Functional study of cellular immunity in brazilians with type 1 diabetes at different stages of the disease and its integration with humoral markers
Grantee:Daniela Franchi Pereira da Silva Camilo
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 16/17404-5 - Study of B lymphocytes subset in peripheral blood of patients with a primary progressive form of multiple sclerosis
Grantee:Leonilda Maria Barbosa dos Santos
Support Opportunities: Regular Research Grants
FAPESP's process: 13/12109-7 - Functional study of cellular immunity in Brazilians with type 1 diabetes at different stages of the disease and its integration with genetic and humoral markers
Grantee:Walkyria Mara Gonçalves Volpini
Support Opportunities: Regular Research Grants
FAPESP's process: 12/04565-0 - Immunoregulatory function of HLA-G molecules in multiple sclerosis and experimental autoimmune encephalomyelitis
Grantee:Leonilda Maria Barbosa dos Santos
Support Opportunities: Regular Research Grants