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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Combination of Fasting, Acute Resistance Exercise, and Protein Ingestion Led to Different Responses of Autophagy Markers in Gastrocnemius and Liver Samples

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Author(s):
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Pinto, Ana P. [1] ; Vieira, Tales S. [2] ; Marafon, Bruno B. [3] ; Batitucci, Gabriela [2] ; Cabrera, Elisa M. B. [4] ; da Rocha, Alisson L. [1] ; Kohama, Eike B. [1] ; Rodrigues, Kellen C. C. [5] ; de Moura, Leandro P. [5] ; Pauli, Jose R. [5] ; Cintra, Dennys E. [5] ; Ropelle, Eduardo R. [5] ; de Freitas, Ellen C. [2, 3] ; da Silva, Adelino S. R. [1, 3]
Total Authors: 14
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Postgrad Program Rehabil & Funct Performance, Ribeirao Preto 14049900, SP - Brazil
[2] State Univ Sao Paulo Julio de Mesquita Filho Arar, Postgrad Program Nutr Sci, Araraquara 14800903, SP - Brazil
[3] Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, Ribeirao Preto 14040907, SP - Brazil
[4] Univ Guadalajara, Hlth Sci Univ Ctr, Inst Translat Nutrigenet & Nutrigen, Dept Mol Biol & Genom, Guadalajara 44100, Jalisco - Mexico
[5] Univ Estadual Campinas, UNICAMP, Sch Appl Sci, Lab Mol Biol Exercise LaBMEx, Limeira 13484350, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: NUTRIENTS; v. 12, n. 3 MAR 2020.
Web of Science Citations: 0
Abstract

The present study verified the responses of proteins related to the autophagy pathway after 10 h of fast with resistance exercise and protein ingestion in skeletal muscle and liver samples. The rats were distributed into five experimental groups: control (CT; sedentary and without gavage after fast), exercise immediately (EXE-imm; after fast, rats were submitted to the resistance protocol and received water by gavage immediately after exercise), exercise after 1 h (EXE-1h; after fast, rats were submitted to the resistance protocol and received water by gavage 1 h after exercise), exercise and supplementation immediately after exercise (EXE/Suppl-imm; after fast, rats were submitted to the resistance protocol and received a mix of casein: whey protein 1:1 (w/w) by gavage immediately after exercise), exercise and supplementation 1 h after exercise (EXE/Suppl-1h; after fast, rats were submitted to the resistance protocol and received a mix of casein: whey protein 1:1 (w/w) by gavage 1 h after exercise). In summary, the current findings show that the combination of fasting, acute resistance exercise, and protein blend ingestion (immediately or 1 h after the exercise stimulus) increased the serum levels of leucine, insulin, and glucose, as well as the autophagy protein contents in skeletal muscle, but decreased other proteins related to the autophagic pathway in the liver. These results deserve further mechanistic investigations since athletes are combining fasting with physical exercise to enhance health and performance outcomes. (AU)

FAPESP's process: 17/09038-1 - EFFECTS OF REGULAR PHYSICAL EXERCISE AND OVERTRAINING ON THE BEHAVIOR OF THE AUTOPHAGIC PATHWAY IN DIFFERENT TISSUES OF MICE.
Grantee:Adelino Sanchez Ramos da Silva
Support type: Regular Research Grants