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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Time-related immunomodulation by stressors and corticosterone transdermal application in toads

Full text
Author(s):
Monteiro Titon, Stefanny Christie [1] ; Titon Jr, Braz ; Giorgi Barsotti, Adriana Maria [2] ; Gomes, Fernando Ribeiro [2] ; Assis, Vania Regina [2]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Inst Biociencias, Dept Fisiol, Sao Paulo, SP - Brazil
[2] Titon Jr, Jr., Braz, Univ Sao Paulo, Inst Biociencias, Dept Fisiol, Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: PLoS One; v. 14, n. 9 SEP 20 2019.
Web of Science Citations: 1
Abstract

Immune responses have been mostly studied at a specific time in anuran species. However, time-changes related to immunomodulation associated with glucocorticoid (GC) alterations following stressors and GC treatment are complex. The present study describes time-related changes in immune response and corticosterone (CORT) plasma levels following restraint challenge, short, mid and long-term captivity, and CORT exogenous administration by transdermal application (TA) in Rhinella ornata toads. We observed increased neutrophil: lymphocyte ratios after restraint challenge and CORT TA, without changes following short and mid-term captivity. Plasma bacterial killing ability was sustained in all treatments, except long-term captivity, with decreased values after 90 days under such conditions. Phagocytic activity of peritoneal cells increased after mid-term captivity, and the phytohemagglutinin swelling response was impaired in those animals treated with CORT TA for 20 consecutive days. Plasma CORT levels increased or were sustained after restraint challenge (depending on initial values), decreased following mid and long-term captivity (for those animals showing high CORT in the field) and increased after 20 days of CORT TA. By performing assessments of time-changes in immune processes and CORT plasma levels in R. ornata, we demonstrate immuno-enhancing effects following restraint, short and mid-term stressors, while long-term stressors and CORT TA promoted immunosuppression in these toads. (AU)

FAPESP's process: 14/16320-7 - Impacts of climate/environmental change on the fauna: an integrative approach
Grantee:Carlos Arturo Navas Iannini
Support Opportunities: Research Program on Global Climate Change - Thematic Grants
FAPESP's process: 11/10560-8 - Plasma leves of corticosterone, testosterone and immunocompetence in Bufonids.
Grantee:Vania Regina de Assis
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 16/05024-3 - Hidric stress and immune response in frogs (Rhinella ornata) inhabiting Atlantic Forest fragments
Grantee:Adriana Maria Giorgi Barsotti
Support Opportunities: Scholarships in Brazil - Doctorate