Dalbergia ecastaphyllum (L.) Taub. and Symphonia globulifera L.f.: The Botanical Sources of Isoflavonoids and Benzophenones in Brazilian Red Propolis

Author(s)

Ccana-Ccapatinta, Gari Vidal ^[1] ; Aldana Mejia, Jennyfer Andrea ^[1] ; Tanimoto, Matheus Hikaru ^[1] ; Groppo, Milton ^[2] ; Andrade Sarmento de Carvalho, Jean Carlos ^[3] ; Bastos, Jairo Kenupp ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Lab Pharmacognosy, Av Cafe S-N, BR-14040903 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Dept Biol, Lab Plant Systemat, Fac Philosophy Sci & Letters Ribeirao Preto, Av Bandeirantes 3900, BR-14040901 Ribeirao Preto, SP - Brazil

^[3] Cooperat Apicultores Canavieiras COAPER, Av Burundanga 1900, BR-45860000 Canavieiras, BA - Brazil

• Document type: Journal article
• Source: Molecules; v. 25, n. 9 MAY 2020.
• Web of Science Citations: 0

Abstract

The Brazilian red propolis (BRP) constitutes an important commercial asset for northeast Brazilian beekeepers. The role of Dalbergia ecastaphyllum (L.) Taub. (Fabaceae) as the main botanical source of this propolis has been previously confirmed. However, in addition to isoflavonoids and other phenolics, which are present in the resin of D. ecastaphyllum, samples of BRP are reported to contain substantial amounts of polyprenylated benzophenones, whose botanical source was unknown. Therefore, field surveys, phytochemical and chromatographic analyses were undertaken to confirm the botanical sources of the red propolis produced in apiaries located in Canavieiras, Bahia, Brazil. The results confirmed D. ecastaphyllum as the botanical source of liquiritigenin (1), isoliquiritigenin (2), formononetin (3), vestitol (4), neovestitol (5), medicarpin (6), and 7-O-neovestitol (7), while Symphonia globulifera L.f. (Clusiaceae) is herein reported for the first time as the botanical source of polyprenylated benzophenones, mainly guttiferone E (8) and oblongifolin B (9), as well as the triterpenoids beta-amyrin (10) and glutinol (11). The chemotaxonomic and economic significance of the occurrence of polyprenylated benzophenones in red propolis is discussed. (AU)

• FAPESP's process: 17/04138-8 - Attainment of chemical, analytical, biological, pharmacological and technological studies to fill the gaps on the development of Brazilian propolis sector
• Grantee: Jairo Kenupp Bastos
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 17/26252-7 - No clinical toxicology studies of red propolis and its botanical source Dalbergia ecastophyllum (L.) Taub.
• Grantee: Jennyfer Andrea Aldana Mejía
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 18/13700-4 - HSCCC method development for the isolation and identification of red propolis constituents
• Grantee: Gari Vidal Ccana Ccapatinta
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 19/01697-1 - Phytochemical study and cytotoxic evaluation of the hexanic fraction and isolated compounds from red propolis produced by Apis mellifera L.
• Grantee: Matheus Hikaru Tanimoto
• Support Opportunities: Scholarships in Brazil - Scientific Initiation