High levels of adiponectin attenuate the detrimental association of adiposity with insulin resistance in adolescents

Author(s):Show less -

Agostinis-Sobrinho, Cesar ^[1] ; de Castro Ferreira Vicente, Sofia Emanuelle ^[2] ; Kievisiene, Justina ^{[1, 3]} ; Lopes, Luis ^[4] ; Damaso, Ana Raimunda ^[2] ; Norkiene, Sigute ^{[1, 3]} ; Rosario, Rafaela ^[5] ; da Silveira Campos, Raquel Munhoz ^{[6, 7]} ; Ramirez-Velez, Robinson ^{[8, 9]} ; Mota, Jorge ^[4] ; Santos, Rute ^[4]

Affiliation

^[1] Klaipeda Univ, Fac Hlth Sci, Herkaus Manto G 84, LT-92294 Klaipeda - Lithuania

^[2] Univ Fed Sao Paulo UNIFESP, Post Grad Program Nutr Paulista Med Sch, Sao Paulo - Brazil

^[3] Ramirez-Velez, Robinson, Navarra Inst Hlth Res, IdiSNA, Navarrabiomed, Navarra, Spain.Agostinis-Sobrinho, Cesar, Klaipeda Univ, Fac Hlth Sci, Herkaus Manto G 84, LT-92294 Klaipeda - Lithuania

^[4] Univ Porto, Res Ctr Phys Act Hlth & Leisure, Fac Sport, Porto - Portugal

^[5] Univ Minho, Nursing Sch Coimbra ESEnfC, Sch Nursing, Hlth Sci Res Unit Nursing UICISA E, P-4710 Braga - Portugal

^[6] Univ Fed Sao Paulo UNIFESP, Dept Biosci, Campus Baixada Santista, Santos, SP - Brazil

^[7] Univ Fed Sao Carlos UFSCar, Dept Physiotherapy, Therapeut Resources Lab, BR-13565905 Sao Carlos, SP - Brazil

^[8] Univ Publ Navarra, Dept Hlth Sci, Navarra - Spain

^[9] Navarra Inst Hlth Res, IdiSNA, Navarrabiomed, Navarra - Spain

• Document type: Journal article
• Source: NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES; v. 30, n. 5, p. 822-828, MAY 7 2020.
• Web of Science Citations: 0

Abstract

Background and aim: This study aimed to: i) examine the differences in insulin resistance (IR) across adiposity levels; and ii) ascertain whether high levels of adiponectin attenuate the detrimental association of adiposity with IR in adolescents. Methods and results: A total of 529 adolescents aged 12-18 years participated in this cross-sectional study (267 girls). Anthropometry and body adiposity parameters {[}body mass index (BMI), sum of skinfolds, body fat percentage (BF %) by bio-impedance analysis and waist circumference (WC)], were measured according to standardized procedures and categorized into age- and sex-specific quartiles. Socioeconomic status, pubertal stage and lifestyle determinants (Mediterranean diet adherence and cardiorespiratory fitness) were gathered and used as confounders. Serum adiponectin and IR (homeostasis model assessment of insulin resistance {[}HOMA-IR] estimated from fasting serum insulin and glucose were assessed. Analysis of covariance (ANCOVA) showed that HOMA-IR increased in a linear fashion throughout the quartiles of all adiposity measures (p < 0.001 for all), independently of age, sex, pubertal stage, socioeconomic status, adherence to the Mediterranean diet and cardiorespiratory fitness. Two-way ANCOVA showed that adolescents in the higher quartile of adiposity for BF%, BMI, WC and skinfolds sum (Q4) presented the highest adiponectin levels, and had 0.77 Standard Deviation (SD), 0.8 SD, 0.85 SD and 0.8 SD lower HOMA-IR, respectively (p < 0.01) than their low adiponectin group counterparts, after adjustments for potential confounders. Conclusion: Higher adiponectin levels may attenuate the detrimental association between adiposity and IR, particularly in subjects with higher adiposity. (C) 2020 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 17/07372-1 - New frontiers in the fight against obesity: digital health education as supporting in the interdisciplinary clinical process
• Grantee: Ana Raimunda Dâmaso
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/14309-9 - Effects of Physical Exercise associate with Phototherapy on Adipogenesis Biomarkers and Transdifferentiation of Adipose Tissue in Adult Obese Women
• Grantee: Raquel Munhoz da Silveira Campos
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 13/08522-6 - New therapeutic perspectives in obesity
• Grantee: Ana Raimunda Dâmaso
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/50414-0 - Influence of hyperleptinemia on inflammatory and atherogenic responses in obese adolescents
• Grantee: Ana Raimunda Dâmaso
• Support Opportunities: Regular Research Grants