Synthesis of nanostructured mesoporous silica-coated magnetic nuclei with polyelectrolyte layers for tetracycline hydrochloride control release

Author(s)

Alavarse, Alex Carvalho ^{[1, 2]} ; de Castro, Carlos Eduardo ^{[1, 3, 2]} ; Andrade, Luana dos Santos ^[4] ; Ferreira, Fabio Furlan ^{[1, 3, 2]} ; Bonvent, Jean Jacques ^{[1, 3, 2]}

Affiliation

^[1] Fed Univ ABC, Ctr Nat & Human Sci CCNH, Ave Estados 5001, BR-09210580 Santo Andre, SP - Brazil

^[2] Fed Univ ABC, Nanomed Strateg Unit, NANOMED, Ave Estados 5001, BR-09210580 Santo Andre, SP - Brazil

^[3] Bonvent, Jean Jacques, Fed Univ ABC, Nanomed Strateg Unit, NANOMED, Ave Estados 5001, BR-09210580 Santo Andre, SP, Brazil.Alavarse, Alex Carvalho, Fed Univ ABC, Ctr Nat & Human Sci CCNH, Ave Estados 5001, BR-09210580 Santo Andre, SP - Brazil

^[4] Fed Univ ABC, Ctr Engn Modeling & Social Sci CECS, Ave Estados 5001, BR-09210580 Santo Andre, SP - Brazil

• Document type: Journal article
• Source: APPLIED NANOSCIENCE; v. 10, n. 9 JUN 2020.
• Web of Science Citations: 0

Abstract

Colloidal drug delivery systems are one of the most promising tools for the treatment of several diseases. We present a synthesis route based on four steps involving mesoporous silica-coated magnetite nanoparticles (MNPs) capped by polyelectrolyte (PE) assembling. The morphology and physical properties of the different components of the system were investigated. The magnetite phase of the iron oxide nanoparticles was identified by X-ray diffraction before their incorporation into the mesoporous silica matrix by a sol-gel process. A MCM-41-like organized hexagonal mesoporous (approximate to 4.2 nm) structure was achieved, as ensured by the alpha(S)-plot model. Polyethylenimine PEI and sodium alginate (ALG) PE layer-by-layer capping were successfully performed by simple successive dispersions of nanoparticles in the PE solution bath. TEM images confirmed a well-organized structure, as also supported by DLS and XPS analyses, which present an increase in diameter size and distinct chemical surface composition after each step of the synthesis. The two successive coatings of the MNPs induced a significative decrease of the magnetic susceptibility but kept sufficient intensity for drug delivery assisted by an external magnetic field. To validate the system as drug delivery, in vitro tetracycline hydrochloride (TCH) loading and release studies were performed in PBS solution for 48 h. It was found that the TCH-loaded uncapped mesoporous silica NPs released more than 90% of TCH after 48 h. Meanwhile, when capped by the PEs, only 30% of the total drug amount was released, due to a hindrance of the drug diffusion by the PE layer. The present work suggests that the combination of the low cost and non-toxic hybrid system proposed has potential use in nanomedicine as a drug delivery vehicle. (AU)

• FAPESP's process: 14/50983-3 - INCT 2014: complex fluids
• Grantee: Antonio Martins Figueiredo Neto
• Support Opportunities: Research Projects - Thematic Grants