Antimicrobial photodynamic therapy with Bixa orellana extract and blue LED in the reduction of halitosis-A randomized, controlled clinical trial

Author(s)

Costa da Mota, Ana Carolina ^[1]

Affiliation

^[1] Nove Julho Univ, Postgrad Program Biophoton Appl Hlth Sci, Vergueiro St, 235-249 Liberdade, BR-01504001 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Photodiagnosis and Photodynamic Therapy; v. 30, JUN 2020.
• Web of Science Citations: 0

Abstract

Background: This study aimed to evaluate the reduction of halitosis when using antimicrobial photodynamic therapy (aPDT) with Bixa orellana extract and blue light-emitting diode (LED). Methods: Forty-four UNINOVE students or employees with a diagnosis of sulfide (H2S) >= 112 ppb in gas chromatography were selected. The patients were randomly divided in groups: Group 1 (n = 15): aPDT with annatto and LED; Group 2 (n = 14): tongue scraping; Group 3 (n = 15): tongue scraping and aPDT. For aPDT, a wasBixa orellana extract used in a concentration of 20 % w/v (Formula e Acao (R), Sao Paulo, Brazil) on the tongue for 2 min, associated with a blue-violet LED (Valo Cordless Ultradent (R) Products, Inc., South Jordan, UT, USA) (395 - 480 nm). Six points were irradiated on the back of the tongue, at wavelength 395 - 480 nm for 20 s, energy of 9.6 J and radiant energy of 6.37 J/cm(2) per point. The results were compared before, immediately after treatment and 7 days after. The Friedman test was used for the intragroup analysis and the Kruskal Wallis test for the intergroup analysis. Results: In all groups, there was a difference between baseline and the value immediately after the treatment. In Groups 1 and 3, there was no difference between the baseline and the 7 days control. Conclusion: There was an immediate reduction of halitosis, but the reduction was not maintained after 7days. (AU)

• FAPESP's process: 19/14229-6 - Comparative study between photodynamic therapy with urucum and LED and probiotics in halitosis reduction: controlled clinical trial
• Grantee: Sandra Kalil Bussadori
• Support Opportunities: Regular Research Grants