InhibitoryKIR2DL2Gene: Risk for Deep Endometriosis in Euro-descendants

Author(s)

Marin, Maria Lucia Carnevale ^{[1, 2]} ; Coelho, Veronica ^{[1, 2, 3, 4]} ; Visentainer, Jeane Eliete Laguila ^[5] ; Alves, Hugo Vicentin ^[5] ; Kohler, Karen Francine ^[1] ; Rached, Marici Rached ^[1] ; Abrao, Mauricio Simoes ^{[6, 7, 8]} ; Kalil, Jorge ^{[1, 2, 3, 4]}

Affiliation

^[1] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Lab Immunol, Heart Inst InCor, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Hosp Clin HCFMUSP, Histocompatibil & Cellular Immunol Lab, LIM 19, Fac Med, Sao Paulo, SP - Brazil

^[3] Natl Inst Sci & Technol iii INCT, Inst Invest Immunol, Sao Paulo, SP - Brazil

^[4] Univ Sao Paulo, Div Clin Immunol & Allergy, Fac Med, Sao Paulo, SP - Brazil

^[5] Univ Estadual Maringa, Dept Basic Hlth Sci, Lab Immunogenet, Maringa, PR - Brazil

^[6] BP, Gynecol Div, Sao Paulo, SP - Brazil

^[7] Univ Sao Paulo, Obstet & Gynecol Dept, Fac Med, Sao Paulo, SP - Brazil

^[8] Rua Sao Sebastiao 550, BR-04708001 Sao Paulo - Brazil

• Document type: Journal article
• Source: REPRODUCTIVE SCIENCES; v. 28, n. 1 JUL 2020.
• Web of Science Citations: 0

Abstract

Endometriosis (EDT) is an inflammatory disease characterized by implantation/growth of endometrial tissue, glands, and/or stroma, outside the uterus. Reduced NK cell cytotoxic activity has been implicated in its pathogenesis, together with other immunologic alterations. We investigated the influence ofKIRgene polymorphisms and their HLA ligand combinations in deep endometriosis (DE) susceptibility. One hundred sixty women with a histological diagnosis of DE and 202 control women without the disease, who underwent laparoscopy, were enrolled. The DE group was subdivided into initial (I/II;n = 60) and advanced stages (III/IV,n = 100).KIRand HLA class I gene polymorphisms were typed by PCR-SSP and sequence-based-typing (SBT), respectively. We observed a significant association ofKIR2DL2, an inhibitory gene of B haplotype, conferring risk for DE in Euro-descendants. Positive associations of Bx haplotype and centromeric AB segments were also found. However, no association with KIR-HLA ligand combination was observed. Our data suggestKIR2DL2gene to be a relevant factor favoring NK inhibition in DE in Euro-descendants, contributing to the defective NK cytotoxic activity and impaired clearance of ectopic endometrial cells in the disease. (AU)

• FAPESP's process: 10/10338-0 - Endometriosis: molecular bases of immune response
• Grantee: Maurício Simões Abrão
• Support Opportunities: Research Projects - Thematic Grants