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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The prominence of the dosage form design to treat ocular diseases

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Author(s):
Campos, Patricia Mazureki [1] ; Petrilli, Raquel [2] ; Lopez, V, Renata F.
Total Authors: 3
Affiliation:
[1] Univ Estadual Ponta Grossa, Dept Pharmaceut Sci, Ponta Grossa, PR - Brazil
[2] Univ Int Integrat Afrobrazilian Lusophony, Inst Hlth Sci, Redencao, CE - Brazil
Total Affiliations: 2
Document type: Review article
Source: International Journal of Pharmaceutics; v. 586, AUG 30 2020.
Web of Science Citations: 1
Abstract

The eye is susceptible to various diseases commonly difficult to treat. To overcome the barriers imposed by this organ for required drugs penetration, technological strategies have been implemented to ocular formulations. Among them are the use of temperature or electric stimuli and the development of nanoparticles. The objective of this review is to present the main barriers to ocular drug delivery and to discuss strategies used in the development of ocular dosage forms, primarily for topical delivery, to increase the local bioavailability of drugs, target their delivery and increase patient compliance. Results obtained in the last years related to the topical administration of liposomes, dendrimers, iontophoresis, among other nanoparticulate systems focused on ophthalmic delivery, will be addressed. Finally, some clinical trials and marketed formulations that use nano technology to topically treat eye diseases will be presented. (AU)

FAPESP's process: 17/05930-7 - Influence of iontophoresis and ultrasound on the release of drugs from dendrimeric liquid crystals
Grantee:Raquel Petrilli
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 14/50928-2 - INCT 2014: Pharmaceutical Nanotechnology: a transdisciplinary approach
Grantee:Maria Vitória Lopes Badra Bentley
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 14/22451-7 - Sustained drug delivery systems targeting the epithelial tissue
Grantee:Renata Fonseca Vianna Lopez
Support Opportunities: Research Projects - Thematic Grants