EBV-negative lymphoepithelial-like carcinoma of the lower lip

Author(s)

Luciana Yamamoto Almeida ^[1] ; Heitor Albergoni Silveira ; Evânio Vilela Silva ; Camila de Oliveira Barbeiro ^[4] ; Joaquim Augusto de Paula ^[5] ; Andreia Bufalino ^[6] ; Alfredo Ribeiro-Silva ^[7] ; Jorge Esquiche León ^[8]

Affiliation

^[1] Universidade Estadual de São Paulo. Faculdade de Odontologia de Araraquara. Medicina Oral - Brasil

^[4] Universidade Estadual de São Paulo. Faculdade de Odontologia de Araraquara. Medicina Oral - Brasil

^[5] Dentista. Estratégia Saúde da Família. Ministério da Saúde do Brasil - Brasil

^[6] Universidade Estadual de São Paulo. Faculdade de Odontologia de Araraquara. Medicina Oral - Brasil

^[7] Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Patologia e Medicina Legal - Brasil

^[8] Universidade de São Paulo. Faculdade de Odontologia de Ribeirão Preto. Patologia Oral - Brasil

• Document type: Journal article
• Source: Autopsy and Case Reports; v. 10, n. 1 2020-10-21.

Abstract

ABSTRACT Lymphoepithelial-like carcinoma (LEC) is a rare malignant neoplasm, which can be associated with Epstein-Barr virus (EBV) infection. Histologically, LEC is an undifferentiated carcinoma with an intermixed reactive lymphoplasmacytic infiltrate. LEC appears to be an uncommon tumor type of lip carcinoma. An 82-year-old white woman presented a lesion on her lower lip that developed over the last year. The lesion was characterized by ulceration with flat edges, hardened base, painful, and absence of regional lymphadenopathy. Microscopical analysis evidenced an intense inflammatory infiltrate, composed of lymphoplasmacytic cells, associated with scarce pleomorphic epithelial cells. Immunohistochemistry highlighted the LEC cells with strong expression of pan-CK AE1/AE3, EMA, p63, and p53. CD138 was also faintly positive. Ki-67 was >85%. In situ hybridization analysis did not show evidence of EBV. A diagnostic of EBV-negative LEC was made. We present an uncommon type of lip carcinoma, which can represent a diagnostic challenge for clinicians and pathologists. (AU)

• FAPESP's process: 16/11419-0 - Clinicopathological correlation of the degree of differentiation, tetraspanin expression, viral agents and cell proliferation in a large sample of squamous cell carcinoma of the head and neck region.
• Grantee: Jorge Esquiche León
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/12734-2 - Comparative immunohistochemical characterization of dendritic cell subgroups and viral oncogenesis in oral and oropharyngeal squamous cell carcinoma
• Grantee: Heitor Albergoni da Silveira
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 16/02713-2 - Effects of erlotinib and gefitinib therapy in combination with all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: in vitro, ex vivo and murine experimental model studies.
• Grantee: Luciana Yamamoto de Almeida
• Support Opportunities: Scholarships in Brazil - Post-Doctoral