Determination of Bisphenol A in Paper Products by Synchronous Fluorescence Spectoscopy and Estimation of Daily Exposure

Author(s)

Matheus Gallimberti ^[1] ; Bruno A. Rocha ^[2] ; Vanessa C. O. Souza ^[3] ; Andres D. Campiglia ^[4] ; Fernando Barbosa Jr ^[5]

Affiliation

^[1] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Laboratório de Toxicologia e Essencialidade de Metais - Brasil

^[2] Universidade Federal de São Paulo. Instituto de Ciências Ambientais, Químicas e Farmacêuticas - Brasil

^[3] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Laboratório de Toxicologia e Essencialidade de Metais - Brasil

^[4] University of Central Florida. Department of Chemistry - Estados Unidos

^[5] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Laboratório de Toxicologia e Essencialidade de Metais - Brasil

• Document type: Journal article
• Source: Journal of the Brazilian Chemical Society; v. 31, n. 10, p. 2146-2154, 2020-10-09.

Abstract

In this study, a simple and fast procedure was developed and validated for the determination of bisphenol A (BPA) in paper products using synchronous fluorescence spectroscopy. The method was used for the determination of BPA in thirteen types of paper products, including thermal receipt papers, lottery tickets, bus tickets, business cards, mailing envelopes, flyers, napkins, printing paper, food contact paper, kitchen rolls, toilet paper, newspapers, and magazines. BPA was found in 98% of thermal receipt papers (n = 341) at concentrations ranging from below the limit of quantification (LOQ) to 27.7 mg g−1 with a geometric mean of 14.6 mg g−1 and a median of 17.7 mg g−1. The detection rate for other paper products was 96%, with BPA concentrations ranging from below the LOQ to 379 µg g−1 and a median of 17.3 µg g−1. The estimated daily intake for the adjusted bodyweight of BPA (calculated at median concentrations) through dermal absorption from handling papers was 14.5 and 1070 ng day−1 for the general population and occupationally-exposed individuals, respectively. The proposed analytical method is simple, fast, and cost-effective for the determination of BPA in paper samples. Moreover, an estimated daily exposure of Brazilians to BPA through dermal absorption from handling different types of papers is shown. (AU)

• FAPESP's process: 13/23710-3 - The use of Shpol'skii spectroscopy and LC-MS/MS for determination of bisphenol A and analogues in urine samples and exposure assessment in children living in the São Paulo State, Brazil
• Grantee: Bruno Alves Rocha
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 18/24069-3 - ReSEARCH: Recognizing Signatures of the Exposome to Anticipate the Risks for a Continuous Health
• Grantee: Fernando Barbosa Júnior
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 12/03465-1 - Novel methodology for the analysis of high-molecular weight polycyclic aromatic hydrocarbons in water and particulate matter samples based on Shpol'skii spectroscopy
• Grantee: Fernando Barbosa Júnior
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/00986-6 - Development of novel methodology for the routine monitoring of monohydroxy metabolites of polycyclic aromatic hydrocarbons in numerous urine samples
• Grantee: Fernando Barbosa Júnior
• Support Opportunities: Research Grants - Visiting Researcher Grant - International