Evaluation of peptidylarginine deiminase 4 and PADI4 polymorphisms in sepsis-induced acute kidney injury

Author(s)

Nara Aline Costa ^[1] ; Bertha Furlan Polegato ^[2] ; Amanda Gomes Pereira ^[3] ; Sérgio Alberto Rupp de Paiva ^[4] ; Ana Lúcia Gut ^[5] ; André Luís Balbi ^[6] ; Daniela Ponce ^[7] ; Leonardo Antonio Mamede Zornoff ^[8] ; Paula Schmidt Azevedo ^[9] ; Marcos Ferreira Minicucci ^[10]

Affiliation

^[1] Universidade Federal de Goiás. Faculdade de Nutrição - Brasil

^[2] Unesp. Faculdade de Medicina de Botucatu - Brasil

^[3] Unesp. Programa de Pós-graduação em Fisiopatologia em Clínica Médica - Brasil

^[4] Unesp. Faculdade de Medicina de Botucatu - Brasil

^[5] Unesp. Faculdade de Medicina de Botucatu - Brasil

^[6] Unesp. Faculdade de Medicina de Botucatu - Brasil

^[7] Unesp. Programa de Pós-graduação em Fisiopatologia em Clínica Médica - Brasil

^[8] Unesp. Faculdade de Medicina de Botucatu - Brasil

^[9] Unesp. Faculdade de Medicina de Botucatu - Brasil

^[10] Unesp. Faculdade de Medicina de Botucatu - Brasil

• Document type: Journal article
• Source: Revista da Associação Médica Brasileira; v. 66, n. 11, p. 1515-1520, 2020-12-02.

Abstract

SUMMARY BACKGROUND: The aim of this study is to evaluate the peptidylarginine deiminase 4 (PAD 4) concentration and PADI4 polymorphisms as predictors of acute kidney injury (AKI) development, the need for renal replacement therapy (RRT), and mortality in patients with septic shock. METHODS: We included all individuals aged ≥ 18 years, with a diagnosis of septic shock at ICU admission. Blood samples were taken within the first 24 hours of the patient's admission to determine serum PAD4 concentration and its PADI4 polymorphism (rs11203367) and (rs874881). Patients were monitored during their ICU stay and the development of SAKI was evaluated. Among the patients in whom SAKI developed, mortality and the need for RRT were also evaluated. RESULTS: There were 99 patients, 51.5% of whom developed SAKI and of these, 21.5% needed RRT and 80% died in the ICU. There was no difference between PAD4 concentration (p = 0.116) and its polymorphisms rs11203367 (p = 0.910) and rs874881 (p = 0.769) in patients in whom SAKI did or did not develop. However, PAD4 had a positive correlation with plasma urea concentration (r = 0.269 and p = 0.007) and creatinine (r = 0.284 and p = 0.004). The PAD4 concentration and PADI4 polymorphisms were also not associated with RRT and with mortality in patients with SAKI. CONCLUSION: PAD4 concentration and its polymorphisms were not associated with SAKI development, the need for RRT, or mortality in patients with septic shock. However, PAD4 concentrations were associated with creatinine and urea levels in these patients. (AU)

• FAPESP's process: 14/17262-0 - Influence of zinc, copper and superoxide dismutase 1 polymorphism on mortality in patients with septic shock
• Grantee: Marcos Ferreira Minicucci
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/07988-4 - Influence of peptidyl deiminase 4 and anti citrullinated antibody on mortality in patients with septic shock
• Grantee: Eloá Siqueira Magalhães
• Support Opportunities: Scholarships in Brazil - Scientific Initiation