Interdisciplinary therapy had positive effects on inflammatory state, mediated by leptin, adiponectin, and quality of diet in obese women

Author(s):Show less -

Shiba, Carolina Kim ^[1] ; Damaso, Ana Raimunda ^[1] ; Rhein, Samantha Ottani ^[1] ; Machado, Paola Prospero ^[1] ; Landi Masquio, Deborah Cristina ^[2] ; Oyama, Lila Missae ^{[1, 3]} ; Barreto Lombardi, Joao Augusto ^[4] ; Lo Duca, Leonardo ^[4] ; Tock, Lian ^[4] ; Oliveira, Gabriela Iervolino ^[4] ; Silveira Campos, Raquel Munhoz ^[5]

Affiliation

^[1] Univ Fed Sao Paulo UNIFESP, Postgrad Program Nutr, Paulista Med Sch, Sao Paulo - Brazil

^[2] Camilo Univ Ctr, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Dept Physiol, Paulista Med Sch, Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo GEO UNIFESP, Obes Study Grp, Sao Paulo - Brazil

^[5] Univ Fed Sao Paulo, Dept Biosci, Campus Baixada Santista, Santos, SP - Brazil

• Document type: Journal article
• Source: NUTRICION HOSPITALARIA; v. 37, n. 3, p. 456-464, MAY-JUN 2020.
• Web of Science Citations: 0

Abstract

Abstract Background: obesity is a chronic disease associated with inadequate eating habits and reduced levels of physical activity. Because of obesity, the risk for comorbidities is increased, especially for cardiovascular diseases, insulin resistance, and increased pro-inflammatory factors. The aim of the present investigation was to analyze potential correlations between pro/anti-inflammatory adipokines, glycemic index, and other markers of diet quality using a metabolic profile in women undergoing interdisciplinary weight loss therapy. Methods: thirty-two women with obesity were enrolled in a 12-week program of interdisciplinary therapy combining a clinical, nutritional, and physical exercise approach. Body composition, quality of diet, metabolic profile, and pro/anti-inflammatory adipokines were analyzed. Results: the therapy showed to be effective in reducing body weight (from 93.16 ± 16.96 to 88.36 ± 16.23; p = 0.0000001), body mass index (from 34.01 ± 4.00 to 32.29 ± 3.96; p = 0.0000001), and body fat (from 38.25 ± 5.05 to 36.13 ± 5; p = 0.0000001). There was also an improvement in lipid profile, including total cholesterol (from 196.16 ± 34.78 to 183.53 ± 43.15; p = 0.001), non-HDL-cholesterol (from 142 ± 30.05 to 1333.69 ± 35.41; p = 0.01), VLDL-cholesterol (from 27.13 ± 12.4 to 22.06 ± 8.55; p = 0.002), triglycerides (from 135.88 ± 61.21 to 110.75 ± 43.09; p = 0.002) and glucose metabolism, including glucose (from 97.13 ± 10.43 to 92.6 ± 6.6; p = 0.004), and insulin (from 13.05 ± 5.54 to 11.29 ± 4.85; p = 0.03). As for food intake, there was a decrease in calorie consumption (from 1991.45 ± 677.78 to 1468.88 ± 390.56; p = 0.002), carbohydrates (from 50.37 ± 6 to 47.04 ± 8.67; p = 0.04), lipids (from 31.83 ± 5.53 to 30.37 ± 7.04; p = 0.3), and glycemic load (from 80.53 ± 39.88 to 54.79 ± 23.69; p = 0.02), and an increased consumption of proteins (from 18.3 ± 2.39 to 22.89 ± 4.9; p = 0.002). Positive correlations were demonstrated between insulin concentration and waist circumference (r = 0.82; p = 0.003); leptin and body fat and abdominal circumference (r = 0.74; p = 0.01); and LDL-cholesterol fraction and total cholesterol consumption (r = 0.69; p = 0.027). Negative correlations were demonstrated between leptin and monosaturated fat consumption (r = -0.71; p = 0.02); and adiponectin and liver enzyme GGT levels (r = -0.65; p = 0.04). Conclusions: interdisciplinary therapy had positive effects on inflammatory state, mediated by leptin, adiponectin, and quality of diet. Our findings suggest the effectiveness and clinical relevance of the interdisciplinary clinical therapy applied for obesity. (AU)

• FAPESP's process: 15/14309-9 - Effects of Physical Exercise associate with Phototherapy on Adipogenesis Biomarkers and Transdifferentiation of Adipose Tissue in Adult Obese Women
• Grantee: Raquel Munhoz da Silveira Campos
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 17/07372-1 - New frontiers in the fight against obesity: digital health education as supporting in the interdisciplinary clinical process
• Grantee: Ana Raimunda Dâmaso
• Support Opportunities: Regular Research Grants