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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Long-Term Characterization of Hippocampal Remapping during Contextual Fear Acquisition and Extinction

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Author(s):
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Schuette, Peter J. [1] ; Reis, V, Fernando M. C. ; Maesta-Pereira, Sandra [2] ; Chakerian, Meghmik [2] ; Torossian, Anita [2] ; Blair, Garrett J. [2] ; Wang, Weisheng [2] ; Blair, Hugh T. [2] ; Fanselow, Michael S. [2] ; Kao, Jonathan C. [3] ; Adhikari, Avishek [2]
Total Authors: 11
Affiliation:
[1] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 - USA
[2] Reis, Fernando M. C., V, Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 - USA
[3] Univ Calif Los Angeles, Dept Elect & Comp Engn, Los Angeles, CA 90095 - USA
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF NEUROSCIENCE; v. 40, n. 43, p. 8329-8342, OCT 21 2020.
Web of Science Citations: 0
Abstract

Hippocampal CA1 place cell spatial maps are known to alter their firing properties in response to contextual fear conditioning, a process called ``remapping.{''} In the present study, we use chronic calcium imaging to examine remapping during fear retrieval and extinction of an inhibitory avoidance task in mice of both sexes over an extended period of time and with thousands of neurons. We demonstrate that hippocampal ensembles encode space at a finer scale following fear memory acquisition. This effect is strongest near the shock grid. We also characterize the long-term effects of shock on place cell ensemble stability, demonstrating that shock delivery induces several days of high fear and low between-session place field stability, followed by a new, stable spatial representation that appears after fear extinction. Finally, we identify a novel group of CA1 neurons that robustly encode freeze behavior independently from spatial location. Thus, following fear acquisition, hippocampal CA1 place cells sharpen their spatial tuning and dynamically change spatial encoding stability throughout fear learning and extinction. (AU)

FAPESP's process: 14/05432-9 - Neural bases of fear and aggression
Grantee:Newton Sabino Canteras
Support type: Research Projects - Thematic Grants
FAPESP's process: 17/08668-1 - In vivo study of GABAergic and glutamatergic neuronal populations of the periaqueductal gray matter in response to different kinds of threat
Grantee:Fernando Midea Cuccovia Vasconcelos Reis
Support type: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 15/23092-3 - Signaling pathways involved in fear memory to predatory threats
Grantee:Fernando Midea Cuccovia Vasconcelos Reis
Support type: Scholarships in Brazil - Post-Doctorate