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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antibacterial activities and antiproliferative assays over a tumor cells panel of a silver complex with 4-aminobenzoic acid: Studies in vitro of sustained release using bacterial cellulose membranes as support

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Simei Aquaroni, Nayara Ap. [1] ; Nakahata, Douglas H. [1] ; Lazarini, Silmara C. [1] ; Resende, Flavia A. [1] ; Candido, Amanda L. P. [1] ; Barud, Hernane da Silva [1] ; Claro, Amanda Maria [1] ; de Carvalho, Joao Ernesto [2] ; Ribeiro, Camila M. [3] ; Pavan, Fernando R. [3] ; Lustri, Bruna C. [3] ; Machado Ribeiro, Tamara Renata [3] ; Moreira, Cristiano G. [3] ; Candido, Tuany Zambroti [4] ; Passos Lima, Carmen Silvia [4] ; Ruiz, Ana Lucia T. G. [2] ; Corbi, Pedro P. [5] ; Lustri, Wilton R. [1]
Total Authors: 18
Affiliation:
[1] Univ Araraquara UNIARA, BR-14801320 Araraquara, SP - Brazil
[2] Univ Campinas UNICAMP, Fac Pharmaceut Sci, BR-13081970 Campinas, SP - Brazil
[3] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14801903 Araraquara, SP - Brazil
[4] Univ Campinas UNICAMP, Fac Med Sci, BR-13081970 Campinas, SP - Brazil
[5] Univ Campinas UNICAMP, Inst Chem, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Journal of Inorganic Biochemistry; v. 212, NOV 2020.
Web of Science Citations: 0
Abstract

The aims of this work were to evaluate the antibacterial and antiproliferative potential in vitro of the metal complex with 4-aminobenzoic acid (Ag-pABA) and a drug delivery system based on bacterial cellulose (BC-Ag-pABA). The Ag-pABA complex was characterized by elemental analysis, high resolution mass spectrometry and single-crystal X-ray diffraction techniques, which indicated a 1:2 metal/pABA composition plus a nitrate ion coordinated to silver by the oxygen atom, with the coordination formula {[}Ag (C7H7NO2)(2)(NO3)]. The coordination of pABA to the silver ion occurred by the nitrogen atom. The in vitro antibacterial activity of the complex evaluated by minimum inhibitory concentration assays demonstrated the effective growth inhibitory activity against Gram-positive, Gram-negative biofilm producers and acid-alcohol resistant Bacillus. The anti proliferative activities against a panel of eight tumor cells demonstrated the activity of the complex with a significant selectivity index (SI). The DNA interaction capacity and the Ames Test indicated the absence of mutagenicity. The BC-Ag-pABA composite showed an effective capacity of sustained release of Ag-pABA. The observed results validate further studies on its mechanisms of action and the conditions that mediate the in vivo biological effects using animal models to confirm its safety and effectiveness for treatment of skin and soft tissues infected by bacterial pathogens, urinary tract infections and cancer. (AU)

FAPESP's process: 17/19243-1 - Characterization of pathogenicity and chemical signaling of prototype strains and clinical samples of uropathogenic Escherichia coli against compound LED209
Grantee:Bruna Cardinali Lustri
Support type: Scholarships in Brazil - Master
FAPESP's process: 15/09833-0 - Sustainable delivery system based on biocellulose/metallic complexes containing bioactive ligands
Grantee:Wilton Rogério Lustri
Support type: Regular Research Grants
FAPESP's process: 17/16278-9 - Study of the genotoxicological potential and permeation assay with Caco-2 cells of metallic complexes with promising biological activities
Grantee:Flávia Aparecida Resende Nogueira
Support type: Regular Research Grants
FAPESP's process: 18/12062-4 - Synthesis, characterization and studies of interaction with biomolecules of metal complexes containing biologically active ligands: a strategy in the preparation of new agents with antibacterial and antiviral activities
Grantee:Pedro Paulo Corbi
Support type: Regular Research Grants
FAPESP's process: 16/07729-4 - Metal complex from golden, palladium and silver in the treatment of skin squamous cell carcinoma
Grantee:Tuany Zambroti Cândido
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
Grantee:Vanderlei Salvador Bagnato
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 18/12590-0 - Synthesis of metal complexes with bioactive N,N or N,O-coordinating ligands for use in sustainable delivery system based on bacterial cellulose
Grantee:Wilton Rogério Lustri
Support type: Regular Research Grants
FAPESP's process: 18/25512-8 - Biocelulose-based Cell Culture Platform
Grantee:Hernane da Silva Barud
Support type: Regular Research Grants
FAPESP's process: 14/06779-2 - Role of chemical signaling and auxiliary mechanisms in Salmonella enterica serovar Typhimurium virulence and other enteropathogens
Grantee:Cristiano Gallina Moreira
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 19/03049-7 - Transcriptome of the bacterial chemical signaling in Salmonella Typhimurium, emergent global bacterial enteropathogens investigation in São Paulo, and alternative infection model employed to study pathogenesis
Grantee:Cristiano Gallina Moreira
Support type: Regular Research Grants
FAPESP's process: 18/02344-2 - Evaluation of in vitro and in vivo potential of siderophores-functionalized liposomes containing moxifloxacin against Mycobacterium tuberculosis
Grantee:Camila Maríngolo Ribeiro
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 18/00163-0 - Development and search of new antimicrobials against Tuberculosis: from screening to pre-clinical studies in vivo
Grantee:Fernando Rogério Pavan
Support type: Regular Research Grants
FAPESP's process: 15/20882-3 - Metal complexes of sulfamethoxydiazine and sulfadimethoxine: synthesis, characterization and applications as antimicrobial agents for topical use
Grantee:Douglas Hideki Nakahata
Support type: Scholarships in Brazil - Doctorate