Current applications of drug delivery nanosystems associated with antimicrobial photodynamic therapy for oral infections

Author(s)

Polli Silvestre, Amanda Leticia ^[1] ; Di Filippo, Leonardo Delello ^[1] ; Besegato, Joao Felipe ^[2] ; de Annunzio, Sarah Raquel ^[3] ; Furquim de Camargo, Bruna Almeida ^[1] ; Gobbo de Melo, Priscila Borges ^[2] ; de Souza Rastelli, Alessandra Nara ^[2] ; Fontana, Carla Raquel ^[3] ; Chorilli, Marlus ^[1]

Affiliation

^[1] Sao Paulo State Univ, Sch Pharmaceut Sci, Dept Drugs & Med, UNESP, BR-14801903 Araraquara, SP - Brazil

^[2] Sao Paulo State Univ, Sch Dent, Dept Restorat Dent, UNESP, BR-14801903 Araraquara, SP - Brazil

^[3] Sao Paulo State Univ, Sch Pharmaceut Sci, Dept Clin Anal, UNESP, BR-14801903 Araraquara, SP - Brazil

• Document type: Review article
• Source: International Journal of Pharmaceutics; v. 592, JAN 5 2021.
• Web of Science Citations: 0

Abstract

The oral cavity is colonized by several species of microorganisms that can cause dental caries, periodontal diseases, candidiasis, endodontic infections, and, among other diseases related to the dental field. Conventional treatment consists of mechanical removal associated with systemic administration of antimicrobials, which can cause various side effects and microbial resistance. In this context, alternative therapies have been developed, including Antimicrobial Photodynamic Therapy (aPDT). For the improvement of therapy, the implementation of nanotechnology is very important to optimize the delivery system of the dyes or photosensitizers on biological targets. Besides, this combination provides a non-invasive treatment, better solubility and bioavailability, delivery to the target site, controlled release and protection against external and physical-chemical factors, low side effects, and, unlikely resistant species. Although, there are numerous researches on aPDT and nanotechnology, few review articles based on the combination of these three aspects: nanosystems, aPDT and oral infections are available. For this reason, this article aims to discuss the advances and advantages of this combination. Therefore, this article was divided into different types of nanosystems (organic and inorganic nanoparticles) associated with aPDT bringing a description of it is definitions, properties, and, applications in oral infections. (AU)

• FAPESP's process: 18/23015-7 - Antimicrobial photodynamic therapy by continuous and switched mode irradiation against Enterococcus faecalis and Cutibacterium acnes
• Grantee: Carla Raquel Fontana
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/23096-7 - Evaluation of the potential of sodium alginate films containing curcumin encapsulated in chitosan nanoparticles associated with photodynamic therapy for the treatment of oral biofilms
• Grantee: Amanda Letícia Polli Silvestre
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 18/18488-3 - Potential evaluation of nanostructured lipid carriers functionalized with bevacizumab for delivery of docetaxel in the treatment of glioblastoma
• Grantee: Leonardo Delello Di Filippo
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 18/09088-1 - Assessment of photodynamic therapy against polymicrobial acne biofilms: a preclinical study
• Grantee: Sarah Raquel de Annunzio
• Support Opportunities: Scholarships in Brazil - Doctorate