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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Current advances concerning the most cited metal ions doped bioceramics and silicate-based bioactive glasses for bone tissue engineering

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Schatkoski, Vanessa Modelski [1] ; Montanheiro, Thais Larissa do Amaral [1] ; Canuto de Menezes, Beatriz Rossi [1] ; Pereira, Raissa Monteiro [1] ; Rodrigues, Karla Faquine [1] ; Ribas, Renata Guimaraes [1] ; da Silva, Diego Morais [1] ; Thim, Gilmar Patrocinio [1]
Total Authors: 8
[1] Technol Inst Aeronaut ITA, Lab Plasmas & Proc LAB LPP, Praca Marechal Eduardo Gomes 50, BR-12228900 Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: CERAMICS INTERNATIONAL; v. 47, n. 3, p. 2999-3012, FEB 1 2021.
Web of Science Citations: 0

Studies related to biomaterials that stimulate the repair of living tissue have increased considerably, improving the quality of many people's lives that require surgery due to traumatic accidents, bone diseases, bone defects, and reconstructions. Among these biomaterials, bioceramics and bioactive glasses (BGs) have proved to be suitable for coating materials, cement, scaffolds, and nanoparticles, once they present good biocompatibility and degradability, able to generate osteoconduction on the surrounding tissue. However, the role of biomaterials in hard tissue engineering is not restricted to a structural replacement or for guiding tissue regeneration. Nowadays, it is expected that biomaterials develop a multifunctional role when implanted, orchestrating the process of tissue regeneration and providing to the body the capacity to heal itself. In this way, the incorporation of specific metal ions in bioceramics and BGs structure, including magnesium, silver, strontium, lithium, copper, iron, zinc, cobalt, and manganese are currently receiving enhanced interest as biomaterials for biomedical applications. When an ion is incorporated into the bioceramic structure, a new category of material is created, which has several unique properties that overcome the disadvantages of primitive material and favors its use in different biomedical applications. The doping can enhance handling properties, angiogenic and osteogenic performance, and antimicrobial activity. Therefore, this review aims to summarize the effect of selected metal ion dopants into bioceramics and silicate-based BGs in bone tissue engineering. Furthermore, new applications for doped bioceramics and BGs are highlighted, including cancer treatment and drug delivery. (AU)

FAPESP's process: 18/12035-7 - Mechanical and antimicrobial properties of Ag/PMMA nanocomposite
Grantee:Gilmar Patrocínio Thim
Support type: Regular Research Grants
FAPESP's process: 17/02846-5 - AgVO3/PMMA Nanocomposites: Effect of functionalization with acrilamide on mechanical and antimicrobial properties
Grantee:Beatriz Rossi Canuto de Menezes Rodrigues
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/27079-7 - Reinforcement of a wollastonite cement (CaSiO3) by carbon nanotubes for biomedical or dental applications
Grantee:Renata Guimarães Ribas
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/24873-4 - PHBV and hydroxybutyrate functionalized CNT nanocomposite: kinetic study of crystallization and correlation with mechanical properties
Grantee:Thaís Larissa do Amaral Montanheiro
Support type: Scholarships in Brazil - Post-Doctorate