A Novel Theranostic Platform: Integration of Magnetomotive and Thermal Ultrasound Imaging With Magnetic Hyperthermia

Author(s)

Hadadian, Yaser ^[1] ; Uliana, Joao H. ^[1] ; Carneiro, Antonio A. O. ^[1] ; Pavan, Theo Z. ^[1]

Affiliation

^[1] Univ Sao Paulo, Dept Phys, BR-14040901 Ribeirao Preto - Brazil

• Document type: Journal article
• Source: IEEE Transactions on Biomedical Engineering; v. 68, n. 1, p. 68-77, JAN 2021.
• Web of Science Citations: 3

Abstract

Objective: Nanotheranostic systems integrate therapeutic and diagnostic procedures using nanotechnology. This type of approach has enabled the development of methods for early detection and treatment of different pathologies. Magnetic hyperthermia (MH) has been proposed as an alternative or complementary method of cancer therapy. However, challenges such as delivering and localizing the magnetic nanoparticles (MNPs) within tissues and monitoring the temperature during the treatment hinder this technique to be effectively translated into a clinical routine. Therefore, in this study a theranostic platform has been proposed and examined to address two main issues, localizing MNPs and real-time temperature monitoring, for preclinical MH. Methods: The system integrates magnetomotive (MMUS) and thermal ultrasound imaging with MH. An ultrasound device was used to acquire MMUS images to detect MNPs, and ultrasound thermometry to monitor the temperature. This platform was designed such that a single coil generated the magnetic field for MMUS and MH. The feasibility of the system was examined using a tissue mimicking phantom containing an inclusion filled with zinc substituted magnetite NPs. Results: These MNPs were effectively used as contrast agent for MMUS and to generate heat during MH. In addition to localizing MNPs, real-time two-dimensional temperature maps were obtained with substantial concordance (rho(c) > 0.97) with invasive measurements using fiber optic thermometer. The heating rate was proportional to the displacements in MMUS (r = 0.92). Conclusion: Ultrasound thermometry was successfully used to monitor the temperature during MH. In addition, it was shown that acquiring MMUS images prior to MH can qualitatively predict the temperature distribution of the MNP-laden regions. (AU)

• FAPESP's process: 16/22374-8 - Blood oxygenation analysis in tumors using photoacoustic imaging
• Grantee: João Henrique Uliana
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 13/18854-6 - Photoacoustic and ultrasound imaging applied to tissue characterization
• Grantee: Theo Zeferino Pavan
• Support Opportunities: Research Grants - Young Investigators Grants