| Full text | |
| Author(s): Show less - |
Maria E. R. Coste
[1]
;
Carolina N. França
[2]
;
Maria Cristina Izar
[3]
;
Daniela Teixeira
[4]
;
Mayari E. Ishimura
[5]
;
Ieda Longo-Maugeri
[6]
;
Amanda S. Bacchin
[7]
;
Henrique Tria Bianco
[8]
;
Flavio T. Moreira
[9]
;
Ibraim Masciarelli Pinto
[10]
;
Gilberto Szarf
[11]
;
Adriano Mendes Caixeta
[12]
;
Otavio Berwanger
[13]
;
Iran Gonçalves Jr
[14]
;
Francisco A. H. Fonseca
[15]
Total Authors: 15
|
| Affiliation: Show less - | [1] Universidade Federal de São Paulo - Brasil
[2] Universidade de Santo Amaro - Brasil
[3] Universidade Federal de São Paulo - Brasil
[4] Universidade Federal de São Paulo - Brasil
[5] Universidade Federal de São Paulo - Brasil
[6] Universidade Federal de São Paulo - Brasil
[7] Universidade Federal de São Paulo - Brasil
[8] Universidade Federal de São Paulo - Brasil
[9] Universidade Federal de São Paulo - Brasil
[10] Instituto Dante Pazzanese de Cardiologia - Brasil
[11] Universidade Federal de São Paulo - Brasil
[12] Universidade Federal de São Paulo - Brasil
[13] Hospital Israelita Albert Einstein - Brasil
[14] Universidade Federal de São Paulo - Brasil
[15] Universidade Federal de São Paulo - Brasil
Total Affiliations: 15
|
| Document type: | Journal article |
| Source: | Arquivos Brasileiros de Cardiologia; v. 115, n. 6, p. 1104-1111, 2020-08-28. |
| Abstract | |
Abstract Background Patients with acute myocardial infarction may have a large infarcted area and ventricular dysfunction despite early thrombolysis and revascularization. Objective To investigate the behavior of circulating cytokines in patients with ST-segment elevation myocardial infarction (STEMI) and their relationship with ventricular function. Methods In the BATTLE-AMI (B and T Types of Lymphocytes Evaluation in Acute Myocardial Infarction) trial, patients with STEMI were treated with a pharmacoinvasive strategy. The plasma levels of cytokines (IL-1 β , IL-4, IL-6, IL-10, and IL-18) were tested using enzyme-linked immunosorbent assay (ELISA) at baseline and after 30 days. Infarcted mass and left ventricular ejection fraction (LVEF) were examined by 3-T cardiac magnetic resonance imaging. All p-values < 0.05 were considered statistically significant. Results Compared to baseline, lower levels were detected for IL-1 β (p = 0.028) and IL-18 (p < 0.0001) 30 days after STEMI, whereas higher levels were observed for IL-4 (p = 0.001) and IL-10 (p < 0.0001) at that time point. Conversely, no changes were detected for IL-6 levels (p = 0.63). The levels of high-sensitivity C-reactive protein and IL-6 correlated at baseline (rho = 0.45, p < 0.0001) and 30 days after STEMI (rho = 0.29, p = 0.009). At baseline, correlation between IL-6 levels and LVEF was also observed (rho = -0.50, p = 0.004). Conclusions During the first month post-MI, we observed a marked improvement in the balance of pro- and anti-inflammatory cytokines, except for IL-6. These findings suggest residual inflammatory risk. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0) (AU) | |
| FAPESP's process: | 12/51692-7 - Role of adaptative immunity on the progress of ischemic heart disease after acute myocardial infarction |
| Grantee: | Francisco Antonio Helfenstein Fonseca |
| Support Opportunities: | Research Projects - Thematic Grants |