Effects of Chronic Photobiomodulation with Transcranial Near-Infrared Laser on Brain Metabolomics of Young and Aged Rats

Author(s)

dos Santos Cardoso, Fabrizio ^{[1, 2, 3]} ; dos Santos, Julio Cesar Claudino ^[4] ; Gonzalez-Lima, Francisco ^{[2, 3]} ; Araujo, Bruno Henrique Silva ^[5] ; Lopes-Martins, Rodrigo Alvaro Brandao ^[6] ; Gomes da Silva, Sergio ^{[7, 1, 8]}

Affiliation

^[1] Univ Mogi das Cruzes, Nucl Pesquisas Tecnol, Av Candido Xavier Almeida & Souza 200, BR-08780911 Mogi Das Cruzes, SP - Brazil

^[2] Univ Texas Austin, Dept Psychol, Austin, TX 78712 - USA

^[3] Univ Texas Austin, Inst Neurosci, Austin, TX 78712 - USA

^[4] Univ Fed Sao Paulo, Dept Neurol & Neurosurg, Lab Neurosci, Sao Paulo, SP - Brazil

^[5] Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Biosci Natl Lab LNBio, Campinas, SP - Brazil

^[6] Univ Vale Paraiba Univ, Inst Res & Dev, Lab Biophoton & Expt Therapeut, Sao Jose Dos Campos, SP - Brazil

^[7] Fundacao Cristiano Varella FCV, Hosp Canc Muriae, Muriae, MG - Brazil

^[8] Ctr Univ UNIFAMINAS UNIFAMINAS, Muriae, MG - Brazil

• Document type: Journal article
• Source: Molecular Neurobiology; v. 58, n. 5 JAN 2021.
• Web of Science Citations: 1

Abstract

Since laser photobiomodulation has been found to enhance brain energy metabolism and cognition, we conducted the first metabolomics study to systematically analyze the metabolites modified by brain photobiomodulation. Aging is often accompanied by cognitive decline and susceptibility to neurodegeneration, including deficits in brain energy metabolism and increased susceptibility of nerve cells to oxidative stress. Changes in oxidative stress and energetic homeostasis increase neuronal vulnerability, as observed in diseases related to brain aging. We evaluated and compared the cortical and hippocampal metabolic pathways of young (4 months old) and aged (20 months old) control rats with those of rats exposed to transcranial near-infrared laser over 58 consecutive days. Statistical analyses of the brain metabolomics data indicated that chronic transcranial photobiomodulation (1) significantly enhances the metabolic pathways of young rats, particularly for excitatory neurotransmission and oxidative metabolism, and (2) restores the altered metabolic pathways of aged rats towards levels found in younger rats, mainly in the cerebral cortex. These novel metabolomics findings may help complement other laser-induced neurocognitive, neuroprotective, anti-inflammatory, and antioxidant effects described in the literature. (AU)

• FAPESP's process: 13/08028-1 - CEGH-CEL - Human Genome and Stem Cell Research Center
• Grantee: Mayana Zatz
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 17/16443-0 - Therapeutic potential of low-level laser in the brain of aged rats
• Grantee: Fabrízio dos Santos Cardoso
• Support Opportunities: Scholarships in Brazil - Doctorate