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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Silver nanoparticles stabilized with propolis show reduced toxicity and potential activity against fungal infections

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Author(s):
Kischkel, Brenda [1, 2] ; de Castilho, Pamella F. [3] ; de Oliveira, Kelly M. P. [3] ; Rezende, Pamela S. T. [1] ; Bruschi, Marcos L. [4] ; Svidzinski, Terezinha I. E. [1] ; Negri, Melyssa [1]
Total Authors: 7
Affiliation:
[1] Univ Estadual Maringa, Clin Anal Dept, Ave Colombo 5790, Maringa, PR - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Ave Prof Lineu Prestes 1374, Sao Paulo, SP - Brazil
[3] Fundacao Univ Fed Grande Dourados, Fac Biol & Environm Sci, BR-1761 Dourados, MS - Brazil
[4] Univ Estadual Maringa, Dept Pharm, Ave Colombo 5790, Maringa, PR - Brazil
Total Affiliations: 4
Document type: Journal article
Source: FUTURE MICROBIOLOGY; v. 15, n. 7, p. 521-539, MAY 2020.
Web of Science Citations: 3
Abstract

Aim: Elucidate the antifungal efficacy of biologically synthesized silver nanoparticles with ethanolic propolis extract (AgNPs PE) against the planktonic forms and biofilms of clinically important fungi. Materials \& methods: AgNPs were synthesized, characterized and evaluated for cytotoxicity, mutagenicity and antimicrobial activity. Results: AgNPs PE displayed a colloidal appearance, good stability and size of 2.0-40.0 nm. AgNPs PE demonstrated lower cytotoxicity and nonmutagenic potential. In addition, AgNPs PE displayed antifungal properties against all tested isolates, inhibiting growth at concentrations lower than the cytotoxic effect. Mature biofilms treated for 48 h with AgNPs PE showed significant reduction of viable cells, metabolic activity and total biomass. Conclusion: This is the first time that AgNPs have been synthesized from an ethanolic extract of propolis only, proving antifungal, antibiofilm, atoxic and nonmutagenic properties. (AU)

FAPESP's process: 18/26402-1 - Prospection of new epitopes with vaccine potential in the control of experimental infection by Histoplasma capsulatum
Grantee:Brenda Kischkel
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)