Employing molecularly imprinted polymers in the development of electroanalytical methodologies for antibiotic determination

Author(s)

Benachio, Ingrid ^[1] ; Lobato, Alnilan ^[1] ; Goncalves, Luis Moreira ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, Sao Paulo, SP - Brazil

• Document type: Review article
• Source: JOURNAL OF MOLECULAR RECOGNITION; v. 34, n. 3 MAR 2021.
• Web of Science Citations: 2

Abstract

Antibiotics, although being amazing compounds, need to be monitored in the environment and foodstuff. This is primarily to prevent the development of antibiotic resistance that may make them ineffective. Unsurprisingly, advances in analyticalsciences that can improve their determination are appreciated. Electrochemical techniques are known for their simplicity, sensitivity, portability and low-cost; however, they are often not selective enough without recurring to a discriminating element like an antibody. Molecular imprinting technology aims to create artificial tissues mimicking antibodies named molecularly imprinted polymers (MIPs), these retain the advantages of selectivity but without the typical disadvantages of biological material, like limited shelf-life and high cost. This manuscript aims to review all analytical methodologies for antibiotics, using MIPs, where the detection technique is electrochemical, like differential pulse voltammetry (DPV), square-wave voltammetry (SWV) or electrochemical impedance spectroscopy (EIS). MIPs developed by electropolymerization (e-MIPs) were applied in about 60 publications and patents found in the bibliographic search, while MIPs developed by other polymerization techniques, like temperature assisted ({''}bulk{''}) or photopolymerization, were limited to around 40. Published works covered the electroanalysis of a wide range of different antibiotics (beta-lactams, tetracyclines, quinolones, macrolides, aminoglycosides, among other), in a wide range of matrices (food, environmental and biological). (AU)

• FAPESP's process: 18/14425-7 - A new synergetic path for gas-diffusion microextraction (GDME) making use of molecular imprinted polymers (MIPs)
• Grantee: Luís Francisco Moreira Gonçalves
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 19/25005-1 - Development of molecular printing polymers (MIPs) by electropolymerization
• Grantee: Ingrid Mayara Benachio
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 19/11214-8 - Application of capillary electrophoresis for the determination of aldehydes after extraction by GDME-MIPs
• Grantee: Alnilan Cristina Barros Lobato
• Support Opportunities: Scholarships in Brazil - Master