Functional and Cardiovascular Parameters in Peripheral Artery Disease Patients with Interarm Blood Pressure Difference

Author(s)

Santini, Luiza ^[1] ; Correia, Marilia Almeida ^[2] ; Oliveira, Paulo L. ^[3] ; Puech-Leao, Pedro ^[4] ; Wolosker, Nelson ^[1] ; Cucato, Gabriel G. ^[5] ; Ritti-Dias, Raphael M. ^[3]

Affiliation

^[1] Inst Israelita Ensino & Pesquisa, Grad Program Hlth Sci, Sao Paulo, SP - Brazil

^[2] Univ Nove Julho, Postgrad Program Med, Sao Paulo, SP - Brazil

^[3] Univ Nove Julho, Postgrad Program Rehabil Sci, Sao Paulo, SP - Brazil

^[4] Univ Sao Paulo, Hosp Clin, Dept Vasc Surg, Sao Paulo, SP - Brazil

^[5] Northumbria Univ, Dept Sport Exercise & Rehabil, Newcastle Upon Tyne, Tyne & Wear - England

• Document type: Journal article
• Source: ANNALS OF VASCULAR SURGERY; v. 70, p. 355-361, JAN 2021.
• Web of Science Citations: 0

Abstract

Background: To analyze the impact of interarm blood pressure difference (IAD) on functional and cardiovascular parameters in patients with peripheral artery disease (PAD). Methods: Ninety-eight patients with PAD were recruited in this cross-sectional study. Patients with differences between the right and left arms of systolic and/or diastolic blood pressure >= 10 mm Hg were classified as IAD, whereas the remaining patients were classified as PAD control subjects. Functional parameters included were the 6-min walk test, short physical performance battery, walking impairment questionnaire (WIQ), and the walking estimated-limitation calculated by history. Systemic cardiovascular parameters included were arterial stiffness and heart rate variability. Local cardiovascular parameters assessed in both arms were brachial blood pressure and flow-mediated dilation. Results: Patients with IAD presented higher systolic blood pressure and pulse pressure compared with control patients (P < 0.01). The carotid femoral pulse wave velocity tended to be higher and flow-mediated dilation tended to be lower in PAD patients with IAD compared with control subjects (P < 0.09). Patients with IAD presented lower scores in short physical performance battery (P = 0.012), WIQ distance (P = 0.003), WIQ speed (P = 0.008), WIQ stair climbing (P = 0.034), and walking estimated-limitation calculated by history (P = 0.026) when compared with PAD control patients. Conclusions: In patients with PAD, IAD is associated with lower physical function and impairments in cardiovascular parameters compared with PAD patients without IAD. (AU)

• FAPESP's process: 16/16425-9 - Effects of handgrip isometric training on blood pressure, endothelial function and cardiac autonomic modulation in patients with peripheral artery disease: a randomized controlled study.
• Grantee: Raphael Mendes Ritti Dias
• Support Opportunities: Regular Research Grants