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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

COVID-19 Disease Course in Former Smokers, Smokers and COPD Patients

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Alberca, Ricardo Wesley [1] ; Lima, Julia Cataldo [1] ; de Oliveira, Emily Araujo [2, 1] ; Gozzi-Silva, Sarah Cristina [2, 1] ; Leuzzi Ramos, Yasmim Alefe [1] ; de Souza Andrade, Milena Mary [1] ; Beserra, Danielle Rosa [1] ; Oliveira, Luana de Mendonca [2, 1] ; Calvielli Castelo Branco, Anna Claudia [2, 1] ; Pietrobon, Anna Julia [2, 1] ; Pereira, Natalli Zanete [1] ; Emidio Teixeira, Franciane Mouradian [2, 1] ; Fernandes, Iara Grigoletto [1] ; da Silva Duarte, Alberto Jose [1] ; Benard, Gil [1] ; Sato, Maria Notomi [1]
Total Authors: 16
[1] Univ Sao Paulo, Dept Dermatol, Lab Dermatol & Imunodeficiencias LIM 56, Fac Med FMUSP, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: FRONTIERS IN PHYSIOLOGY; v. 11, JAN 27 2021.
Web of Science Citations: 2

The severe respiratory and systemic disease named coronavirus disease-2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, the COVID-19 pandemic presents a huge social and health challenge worldwide. Many different risk factors are associated with disease severity, such as systemic arterial hypertension, diabetes mellitus, obesity, older age, and other co-infections. Other respiratory diseases such as chronic obstructive pulmonary disease (COPD) and smoking are common comorbidities worldwide. Previous investigations have identified among COVID-19 patients smokers and COPD patients, but recent investigations have questioned the higher risk among these populations. Nevertheless, previous reports failed to isolate smokers and COPD patients without other comorbidities. We performed a longitudinal evaluation of the disease course of smokers, former smokers, and COPD patients with COVID-19 without other comorbidities, from hospitalization to hospital discharge. Although no difference between groups was observed during hospital admission, smokers and COPD patients presented an increase in COVID-19-associated inflammatory markers during the disease course in comparison to non-smokers and former smokers. Our results demonstrated that smoking and COPD are risk factors for severe COVID-19 with possible implications for the ongoing pandemic. (AU)

FAPESP's process: 19/02679-7 - Effect of maternal and paternal supplementation with antioxidant in pulmonary inflammatory process of the offspring of mice
Grantee:Ricardo Wesley Alberca Custódio
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/18199-9 - Effect of maternal supplementation with retinoic acid during breastfeeding on the immune response of mice offspring
Grantee:Maria Notomi Sato
Support type: Regular Research Grants