The role of polysaccharides from natural resources to design oral insulin micro- and nanoparticles intended for the treatment of Diabetes mellitus: A review

Author(s)

Meneguin, Andreia Bagliotti ^[1] ; Silvestre, Amanda Leticia Polli ^[1] ; Sposito, Larissa ^[1] ; de Souza, Mauricio Palmeira Chaves ^[1] ; Sabio, Rafael Miguel ^[1] ; Araujo, Victor Hugo Sousa ^[1] ; Cury, Beatriz Stringhetti Ferreira ^[1] ; Chorilli, Marlus ^[1]

Affiliation

^[1] Sao Paulo State Univ, Sch Pharmaceut Sci, BR-14800903 Araraquara, SP - Brazil

• Document type: Review article
• Source: Carbohydrate Polymers; v. 256, MAR 15 2021.
• Web of Science Citations: 0

Abstract

Oral administration of insulin (INS) would represent a revolution in the treatment of diabetes, considering that this route mimics the physiological dynamics of endogenous INS. Nano- and microencapsulation exploiting the advantageous polysaccharides properties has been considered an important technological strategy to protect INS against harsh conditions of gastrointestinal tract, in the same time that improve the permeability via transcellular and/or paracellular pathways, safety and in some cases even selectivity for targeting delivery of INS. In fact, some polysaccharides also give to the systems functional properties such as pH-responsiveness, mucoadhesiveness under specific physiological conditions and increased intestinal permeability. In general, all polysaccharides can be functionalized with specific molecules becoming more selective to the cells to which INS is delivered. The present review highlights the advances in the past 10 years on micro- and nanoencapsulation of INS exploiting the unique natural properties of polysaccharides, including chitosan, starch, alginate, pectin, and dextran, among others. (AU)

• FAPESP's process: 19/09597-6 - Gastroretentive microparticles containing trans resveratrols nanoparticle applied to the treatment of Helicobacter pylori infections
• Grantee: Larissa Sposito
• Support type: Scholarships in Brazil - Doctorate
• FAPESP's process: 14/50928-2 - INCT 2014: Pharmaceutical Nanotechnology: a transdisciplinary approach
• Grantee: Maria Vitória Lopes Badra Bentley
• Support type: Research Projects - Thematic Grants
• FAPESP's process: 19/19817-3 - Bioresponsive systems based on retrograded starch/pectin containing cellulose nanofibers as a strategy for 5-ASA colonic delivery in the treatment of Inflammatory Bowel Disease
• Grantee: Andréia Bagliotti Meneguin
• Support type: Scholarships in Brazil - Post-Doctorate