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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Application of MIL-100(Fe) in drug delivery and biomedicine

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Author(s):
Quijia, Christian Rafael [1] ; Lima, Camila [2] ; Silva, Caroline [2] ; Alves, Renata Carolina [1] ; Frem, Regina [2] ; Chorilli, Marlus [1]
Total Authors: 6
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Araraquara, SP - Brazil
[2] Sao Paulo State Univ UNESP, Chem Inst, Araraquara, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY; v. 61, FEB 2021.
Web of Science Citations: 0
Abstract

Metal-organic frameworks (MOFs) are an interesting and advantageous class of coordination polymers, constructed from metal ion/clusters and organic linkers. They have attracted growing research interest over the past decades and captured attention in the field of biomedical applications due to their high drug loading capacity, post-synthetic modification, and the ability to synthesize at the nanoscale size. In particular, MIL-100(Fe) is a mesoporous, environmentally friendly, and water-stable material. This review summarizes and discusses the recent advances in the synthesis of the micro and nano-MIL-100(Fe), the physicochemical stability concerning changes in pH, temperature, and physiological conditions, as well as biomedical applications such as biosensors, phototherapy, encapsulation methods, and drug release. Finally, future challenges and perspectives in this field are presented. (AU)

FAPESP's process: 18/21119-0 - Evaluation of the potential of piperine encapsulated in metal-organic frameworks coated with macrophage membranes in the treatment of Breast Cancer
Grantee:Christian Rafael Quijia Quezada
Support Opportunities: Scholarships in Brazil - Doctorate