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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lactate does not activate the carotid body of Wistar rat

Full text
Author(s):
Spiller, Pedro F. [1] ; da Silva, Melina P. [1] ; Moraes, Davi J. A. [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Dept Physiol, Sch Med Ribeir ao Preto, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Respiratory Physiology & Neurobiology; v. 285, MAR 2021.
Web of Science Citations: 0
Abstract

The carotid body's glomus cells are the primary sensors of hypoxia in mammals. Previous studies suggested that the glomus cells' hypoxia sensitivity is mediated by lactate in mice. This molecule increases the intracellular {[}Ca2+] and induces exocytosis in glomus cells, activating the carotid sinus nerve (the axons of chemoreceptive petrosal neurons). On the other hand, how lactate affects the activity of carotid body of rats is still unknown. We hypothesized that lactate activates the carotid body of rats. In Wistar rats, we measured the changes in the electrical properties of isolated glomus cells and petrosal chemoreceptive neurons in in situ preparations in response to different concentrations of lactate. Superfusion of both physiological and supraphysiological concentrations of lactate did not affect the membrane conductance and potential of glomus cells. Moreover, lactate injected into the carotid body did not activate the anatomically and physiologically identified chemoreceptive petrosal neurons. We conclude that the carotid body of Wistar rats is not sensitive to lactate. (AU)

FAPESP's process: 16/24869-4 - Participation of lactate and carotid bodies in the respiratory responses of rats submitted to anaerobic physical exercise
Grantee:Pedro Favoretto Spiller
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 18/07027-5 - Role of astrocytes in the excitability of magnocelular neurons form supraoptic nucleus during changes in the plasma osmolality
Grantee:Melina Pires da Silva
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 13/10484-5 - Electrophysiological and molecular characterization of neurons involved in the generation of respiratory rhythm and pattern of rats during postnatal development
Grantee:Davi José de Almeida Moraes
Support Opportunities: Research Grants - Young Investigators Grants