Engineering multifunctional bactericidal nanofibers for abdominal hernia repair

Author(s):Show less -

Afewerki, Samson ^{[1, 2]} ; Bassous, Nicole ^[3] ; Harb, Samarah Vargas ^{[4, 3]} ; Corat, Marcus Alexandre F. ^[5] ; Maharjan, Sushila ^{[1, 2]} ; Ruiz-Esparza, Guillermo U. ^{[1, 2]} ; de Paula, Mirian M. M. ^[5] ; Webster, Thomas J. ^[3] ; Tim, Carla Roberta ^[6] ; Viana, Bartolomeu Cruz ^{[7, 8]} ; Wang, Danquan ^[3] ; Wang, Xichi ^{[1, 2]} ; Marciano, Fernanda Roberta ^{[7, 3]} ; Lobo, Anderson Oliveira ^{[9, 1, 2, 8]}

Affiliation

^[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Engn Med, Boston, MA 02115 - USA

^[2] Harvard Univ, MIT, Div Hlth Sci & Technol, Cambridge, MA 02139 - USA

^[3] Northeastern Univ, Dept Chem Engn, Nanomed Lab, Boston, MA 02115 - USA

^[4] Sao Paulo State Univ UNESP, Inst Chem, Araraquara, SP - Brazil

^[5] Univ Campinas UNICAMP, Multidisciplinary Ctr Biol Res, Campinas, SP - Brazil

^[6] Brasil Univ, Sao Paulo - Brazil

^[7] Univ Fed Piaui, Dept Phys, Teresina, Piaui - Brazil

^[8] UFPI Fed Univ Piaui, Mat Sci & Engn Grad Program, LIMAV Interdisciplinary Lab Adv Mat, Teresina, Piaui - Brazil

^[9] MIT, Dept Chem, Cambridge, MA 02139 - USA

• Document type: Journal article
• Source: COMMUNICATIONS BIOLOGY; v. 4, n. 1 FEB 19 2021.
• Web of Science Citations: 0

Abstract

The engineering of multifunctional surgical bactericidal nanofibers with inherent suitable mechanical and biological properties, through facile and cheap fabrication technology, is a great challenge. Moreover, hernia, which is when organ is pushed through an opening in the muscle or adjacent tissue due to damage of tissue structure or function, is a dire clinical challenge that currently needs surgery for recovery. Nevertheless, post-surgical hernia complications, like infection, fibrosis, tissue adhesions, scaffold rejection, inflammation, and recurrence still remain important clinical problems. Herein, through an integrated electrospinning, plasma treatment and direct surface modification strategy, multifunctional bactericidal nanofibers were engineered showing optimal properties for hernia repair. The nanofibers displayed good bactericidal activity, low inflammatory response, good biodegradation, as well as optimal collagen-, stress fiber- and blood vessel formation and associated tissue ingrowth in vivo. The disclosed engineering strategy serves as a prominent platform for the design of other multifunctional materials for various biomedical challenges. Afewerki et al. employ integrated electrospinning, plasma treatment and direct surface modification strategy to engineer multifunctional bactericidal nanofibers for use in hernia repair. In a mouse model, they demonstrate that these nanofibers display good biological performance with low inflammatory response, good biodegradation and optimal collagen and blood vessel formation and tissue growth. (AU)

• FAPESP's process: 17/02899-1 - Biocompatibility analysis of PMMA-TiO2 and PMMA-ZrO2 organic-inorganic hybrids coatings deposited on Ti6Al4V titanium alloy
• Grantee: Samarah Vargas Harb
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate