Association between polymorphism in gene related to the dopamine circuit and motivations for drinking in patients with alcohol use disorder

Author(s)

Cespedes, Isabel Cristina ^[1] ; Ota, Vanessa Kiyomi ^[1] ; Mazzotti, Diego Robles ^[2] ; Wscieklica, Tatiana ^[3] ; Conte, Rafael ^[1] ; Galduroz, Jose Carlos Fernandes ^[4] ; Varela, Patricia ^[5] ; Pesquero, Joao Bosco ^[5] ; Souza-Formigoni, Maria Lucia Oliveira ^[4]

Affiliation

^[1] Univ Fed Sao Paulo UNIFESP, Dept Morphol & Genet, Rua Botucatu 740, 1o Andar, BR-04023900 Sao Paulo, SP - Brazil

^[2] Univ Penn, Chronobiol & Sleep Inst, 125 South 31st St, Philadelphia, PA 19104 - USA

^[3] Univ Fed Sao Paulo UNIFESP, Dept Biosci, Rua Silva Jardim 136, BR-11015020 Santos, SP - Brazil

^[4] Univ Fed Sao Paulo UNIFESP, Dept Psychobiol, Rua Botucatu 862, 1o Andar, BR-04023062 Sao Paulo, SP - Brazil

^[5] Univ Fed Sao Paulo UNIFESP, Dept Biophys, Rua Botucatu 740, 1o Andar, BR-04023900 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: PSYCHIATRY RESEARCH; v. 295, JAN 2021.
• Web of Science Citations: 0

Abstract

The development of alcohol use disorder (AUD) is influenced by genetic, psychological, and social factors. However, the identification of the load of each of these factors and the association between them is still debatable. This study aimed to explore the load of the association between AUD and polymorphisms in genes of the dopaminergic system, as well as with drinking triggers. The study comprised 227 inpatients with AUD and 174 controls. The pattern and motivations for drinking were evaluated using the Alcohol Use Disorders Identification Test (AUDIT) and the Inventory of Drinking Situations (IDS). Analyses of genetic variation in genes encoding dopaminergic were performed using next generation sequencing. We observed an significant association between a polymorphism in DDC (rs11575457) and AUD. Positive reinforcement factors as urges/temptations to drink and pleasant emotion, in isolation, were the significantly related elements to drinking. In addition, negative (physical discomfort) and positive reinforcement factors (testing personal control; pleasant time with others) significantly reinforced the interaction with DDC genetic variant for increased odds of an individual presenting AUD. These results indicated a complex relationship between the dopaminergic system and the drugseeking behavior profiles. (AU)

• FAPESP's process: 13/01158-7 - Analysis of the influence of genetic polymorphism associated with peptide receptors and family CRF and environmental stress in the development of alcohol dependence
• Grantee: Isabel Cristina Céspedes
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/27198-8 - Establishment of a center of genetic and molecular research for clinical challenges
• Grantee: João Bosco Pesquero
• Support Opportunities: Research Projects - Thematic Grants