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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Multi-Purpose Microwave Biosensor Based on Signal Encoding Technique and Microfluidics for Improved Sensitivity

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Author(s):
Souza, Mateus I. O. [1] ; Mota, Achiles Fontana Da [2] ; Pepino, Vinicius Marrara [1] ; Carmo, Joao Paulo [1] ; Borges, Ben-Hur Viana [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Dept Elect & Comp Engn, Sao Carlos Sch Engn, BR-13566590 Sao Paulo - Brazil
[2] Univ Brasilia, Dept Elect Engn, BR-70910900 Brasilia, DF - Brazil
Total Affiliations: 2
Document type: Journal article
Source: IEEE SENSORS JOURNAL; v. 21, n. 4, p. 4571-4581, FEB 15 2021.
Web of Science Citations: 0
Abstract

In this paper, a microwave biosensor with unprecedented sensitivity based on encoded pulse propagation and microfluidics is theoretically investigated and experimentally demonstrated. The structure consists of a double-spiral transmission line on FR4 substrate electromagnetically coupled to a copper coiled capillary tube above it. The working principle for improved sensitivity consists of propagating an encoded sequence of short pulses (Walsh-Hadamard spreading code with variable temporal length) in a recirculating manner so that the pulses are deformed both due to dispersive and time-delay effects. Once the recirculation is finished, the energy of the code at the sensor output is calculated, providing an indicator directly related with the analyte concentration. The experimental results demonstrate the improved sensitivity of this sensor approach for the case of glucose with 2.9 mg/ml resolution. Furthermore, we demonstrate the potential of this technology as a sensor platform by investigating other chemical compounds such as isopropyl alcohol (IPA) and acetone with a sensitivity of 20% of the volume. Finally, the outstanding performance, both in terms of accuracy and sensitivity, situates the present multi-purpose approach within the state-of-the-art of microwave (bio)chemical sensors. (AU)

FAPESP's process: 19/05248-7 - CMOS microdevice to enable new brain stimulation therapies
Grantee:João Paulo Pereira Do Carmo
Support Opportunities: Regular Research Grants
FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
Grantee:Vanderlei Salvador Bagnato
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC