| Full text | |
| Author(s): Show less - |
Paixao, Vitoria
[1]
;
Almeida, Ewin B.
[1]
;
Amaral, Jonatas B.
[1]
;
Roseira, Tamaris
[2, 1]
;
Monteiro, Fernanda R.
[2, 1]
;
Foster, Roberta
[2, 1]
;
Sperandio, Adriane
[2]
;
Rossi, Marcelo
[1]
;
Amirato, Gislene R.
[1]
;
Santos, Carlos A. F.
[3]
;
Pires, Renier S.
[4]
;
Leal, Fabyano B.
[5]
;
Durigon, Edison L.
[5, 6]
;
Oliveira, Danielle B. L.
[7, 5]
;
Vieira, Rodolfo P.
[8, 9, 10]
;
Vaisberg, Mauro
[1]
;
Santos, Juliana M. B.
[10]
;
Bachi, Andre L. L.
[8, 1, 4]
Total Authors: 18
|
| Affiliation: | [1] Fed Univ Sao Paulo UNIFESP, Dept Otorhinolaryngol, ENT Lab, BR-04021001 Sao Paulo - Brazil
[2] Method Fac Sao Paulo FAMESP, BR-04046200 Sao Paulo - Brazil
[3] Paulista Sch Med EPM, Dept Med, Geriatry, BR-04023062 Sao Paulo - Brazil
[4] Santo Amaro Univ UNISA, Postgrad Program Hlth Sci, BR-04743030 Sao Paulo - Brazil
[5] Univ Sao Paulo, Inst Biomed Sci, BR-05508060 Sao Paulo - Brazil
[6] Univ Sao Paulo, Sci Platform Pasteur, BR-05508060 Sao Paulo - Brazil
[7] Hosp Israelita Albert Einstein, BR-05652900 Sao Paulo - Brazil
[8] Brazilian Inst Teaching & Res Pulm & Exercise Imm, BR-12245520 Sao Paulo - Brazil
[9] Univ Brasil, Postgrad Program Bioengn & Biomed Engn, BR-15600000 Sao Paulo - Brazil
[10] Fed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human & Rehabil, BR-11015020 Santos, SP - Brazil
Total Affiliations: 10
|
| Document type: | Journal article |
| Source: | VACCINES; v. 9, n. 2 FEB 2021. |
| Web of Science Citations: | 1 |
| Abstract | |
Background: Although glutamine is able to improve the immune response, its action in the upper airway immunity against the influenza virus vaccine remains unclear. Therefore, we aimed to evaluate the L-glutamine supplementation effect on the mucosal immune/inflammatory response of elderly subjects vaccinated against the influenza virus. Methods: Saliva sampling from 83 physically active elderly volunteers were collected pre- and 30 days after influenza virus vaccination and supplementation with L-glutamine (Gln, n = 42) or placebo (PL, n = 41). Results: Gln group showed higher salivary levels of interleukin (IL)-17, total secretory immunoglobulin A (SIgA), and specific-SIgA post-vaccination than values found pre-vaccination and in the PL group post-vaccination. Whereas higher salivary levels of IL-6 and IL-10 were observed post-vaccination in the Gln group, IL-37 levels were lower post-vaccination in both groups than the values pre-vaccination. Tumor necrosis factor (TNF)-alpha levels were unchanged. Positive correlations between IL-6 and IL-10 were found in all volunteer groups pre- and post-vaccination and also between IL-17 and IL-6 or IL-10 in the Gln group post-vaccination. A negative correlation between IL-37 and IL-10 was found pre- and post-vaccination in the PL group. Conclusion: Gln supplementation was able to modulate salivary cytokine profile and increase SIgA levels, both total and specific to the influenza virus vaccine, in physically active elderly subjects. (AU) | |
| FAPESP's process: | 19/13188-4 - STUDY OF THE EFFECTS OF GLUTAMINE SUPPLEMENTATION ON THE IMMUNOPHENOTYPING AND ACTIVATION PROFILE OF T AND B LYMPHOCYTES FROM PRACTICING OR NON-EXERCISING SENIORS SUBMITTED TO INFLUENZA VIRUS VACCINATION |
| Grantee: | Tamaris Roseira dos Reis Pavao |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 19/13094-0 - Evaluation of the influence of combined physical exercise and L-glutamine supplementation on the inflammatory profile and response of specific antibodies to the vaccine against the influenza virus in elderly people |
| Grantee: | Fernanda Rodrigues Monteiro |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals |
| Grantee: | Rodolfo de Paula Vieira |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 19/14115-0 - Influence of L-glutamine supplementation in the sarcopenia and immune/inflammatory response both systemic and in the respiratory tract of elderly practitioners or not of a regular program of combined physical exercises submitted to Influenza virus vaccine |
| Grantee: | André Luis Lacerda Bachi |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 10/50025-1 - Influência da atividade física na resposta imune sistêmica e da mucosa das vias aéreas superiores de idosos submetidos a vacinação contra doenças respiratórias |
| Grantee: | André Luis Lacerda Bachi |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |