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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Assessing the Influence of Dyes Physico-Chemical Properties on Incorporation and Release Kinetics in Silk Fibroin Matrices

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Author(s):
Tomoda, Bruno Thorihara [1] ; Pacheco, Murilo Santos [1] ; Abranches, Yasmin Broso [1] ; Vigano, Juliane [1] ; Perrechil, Fabiana [1] ; De Moraes, Mariana Agostini [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo, Dept Chem Engn, Inst Environm Chem & Pharmaceut Sci, Rua Sao Nicolau 210, BR-09913030 Diadema - Brazil
Total Affiliations: 1
Document type: Journal article
Source: POLYMERS; v. 13, n. 5 MAR 2021.
Web of Science Citations: 0
Abstract

Silk fibroin (SF) is a promising and versatile biodegradable protein for biomedical applications. This study aimed to develop a prolonged release device by incorporating SF microparticles containing dyes into SF hydrogels. The influence of dyes on incorporation and release kinetics in SF based devices were evaluated regarding their hydrophilicity, molar mass, and cationic/anionic character. Hydrophobic and cationic dyes presented high encapsulation efficiency, probably related to electrostatic and hydrophobic interactions with SF. The addition of SF microparticles in SF hydrogels was an effective method to prolong the release, increasing the release time by 10-fold. (AU)

FAPESP's process: 19/08975-7 - Multi-User Equipment approved in grant 2018/15539-6: modular compact rheometer and accessories
Grantee:Fabiana Perrechil Bonsanto
Support Opportunities: Multi-user Equipment Program
FAPESP's process: 18/15539-6 - Biopolymeric systems for co-encapsulation of bioactive compounds
Grantee:Fabiana Perrechil Bonsanto
Support Opportunities: Regular Research Grants