Prevalence of low bone mineral density in postmenopausal breast cancer survivors

Author(s)

Priscila Ferreira Poloni ^[1] ; Michelle Sako Omodei ^[2] ; Jorge Nahas-Neto ^[3] ; Gilberto Uemura ^[4] ; Heloisa De Luca Véspoli ^[5] ; Eliana Aguiar Petri Nahas ^[6]

Affiliation

^[1] Universidade Estadual Paulista Júlio de Mesquita Filho. Faculdade de Medicina de Botucatu. Programa de Pós-Graduação em Ginecologia - Brasil

^[2] Universidade Estadual Paulista Júlio de Mesquita Filho. Faculdade de Medicina de Botucatu. Curso de Graduação em Medicina - Brasil

^[3] Universidade Estadual Paulista Júlio de Mesquita Filho. Faculdade de Medicina de Botucatu. Departamento de Ginecologia e Obstetrícia - Brasil

^[4] Universidade Estadual Paulista Júlio de Mesquita Filho. Faculdade de Medicina de Botucatu. Departamento de Ginecologia e Obstetrícia - Brasil

^[5] Universidade Estadual Paulista Júlio de Mesquita Filho. Faculdade de Medicina de Botucatu. Departamento de Ginecologia e Obstetrícia - Brasil

^[6] Universidade Estadual Paulista Júlio de Mesquita Filho. Faculdade de Medicina de Botucatu. Departamento de Ginecologia e Obstetrícia - Brasil

• Document type: Journal article
• Source: Revista Brasileira de Ginecologia e Obstetrícia; v. 37, n. 1, p. 30-35, 2015-01-00.

Abstract

PURPOSE: To evaluate the prevalence of low bone mineral density (BMD) in postmenopausal breast cancer survivors.METHODS: In this cross-sectional study, 115 breast cancer survivors, seeking healthcare at a University Hospital in Brazil, were evaluated. Eligibility criteria included women with amenorrhea ≥12 months and age ≥45 years, treated for breast cancer and metastasis-free for at least five years. BMD was measured by DEXA at the lumbar spine (L1-L4) and femoral neck. Low BMD was considered when total-spine and/or femoral-neck T-score values were <-1.0 Delphi Score (DP) (osteopenia and osteoporosis). The risk factors for low BMD were assessed by interview. Data were analyzed statistically by the χ2 test and Fisher's exact test.RESULTS: The mean age of breast cancer survivors was 61.6±10.1 years and time since menopause was 14.2±5.6 years, with a mean follow-up of 10.1±3.9 years. Considering spine and femoral neck, 60% of breast cancer survivors had low BMD. By evaluating the risk factors for low BMD, a significant difference was found in the percent distribution for age (higher % of women >50 years with low BMD), personal history of previous fracture (11.6% with low BMD versus 0% with normal BMD) and BMI. A higher frequency of obesity was observed among women with normal BMD (63%) compared to those with low BMD (26.1%) (p<0.05).CONCLUSION: Postmenopausal breast cancer survivors had a high prevalence of osteopenia and osteoporosis. (AU)

• FAPESP's process: 13/02671-0 - Evaluation of bone mineral density in postmenopausal breast Cancer survivors
• Grantee: Michelle Sako Omodei
• Support Opportunities: Scholarships in Brazil - Scientific Initiation