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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Spinal cord stimulation improves motor function and gait in spastic paraplegia type 4 (SPG4): Clinical and neurophysiological evaluation

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Author(s):
Souza, Carolina Pinto de [1] ; Coelho, Daniel Boari [2] ; Campos, Debora da Silva Fragoso [2] ; Ghilardi, Maria Gabriela dos Santos [1] ; Vicente, Edrin Claro de Oliveira [3] ; Gonzalez-Salazar, Carelis [4] ; Junior, Marcondes Cavalcante Fransa [4] ; Barsottini, Orlando Graziani Povoas [5] ; Pedroso, Jose Luiz [5] ; Fonoff, Erich Talamoni [1]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Dept Neurol, Med Sch, Ave Ovideo Pires Campos 785, BR-01231000 Sao Paulo, SP - Brazil
[2] Fed Univ ABC, Biomed Engn, Santo Andre, SP - Brazil
[3] Neurosoft Co, Rua Vergueiro 1855, BR-04101000 Sao Paulo, SP - Brazil
[4] Univ Estadual Campinas, Dept Neurol, Campinas - Brazil
[5] Univ Fed Sao Paulo, Dept Neurol, Sao Paulo, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: PARKINSONISM & RELATED DISORDERS; v. 83, p. 1-5, FEB 2021.
Web of Science Citations: 0
Abstract

Introduction: Hereditary spastic paraplegia is a heterogeneous group of genetic disorders characterized by degeneration of the corticospinal tracts, coursing with progressive weakness and spasticity of the lower limbs. To date, there are no effective treatments for progressive deficits or disease-modifying therapy for those patients. We report encouraging results for spastic paraparesis after spinal cord stimulation. Methods: A 51-year-old woman suffering from progressive weakness and spasticity in lower limbs related to hereditary spastic paraplegia type 4 underwent spinal cord stimulation (SCS) and experienced also significant improvement in motor function. Maximum ballistic voluntary isometric contraction test, continuous passive motion test and gait analysis using a motion-capture system were performed in ON and OFF SCS conditions. Neurophysiologic assessment consisted of obtaining motor evoked potentials in both conditions. Results: Presurgical Spastic Paraplegia Rating Scale (SPRS) score was 26. One month after effective SCS was initiated, SPRS went down to 15. At 12 months follow up, she experienced substantial improvement in motor function and in gait performance, with SPRS scores 23 (OFF) and down to 20 (ON). There was an increased isometric muscle strength (knee extension, OFF: 41 N.m; ON: 71 N.m), lower knee extension and flexion torque values in continuous passive motion test (decrease in spastic tone) and improvement in gait (for example, step length increase). Conclusion: Despite being a case study, our findings suggest innovative lines of research for the treatment of spastic paraplegia. (AU)

FAPESP's process: 19/06604-1 - Biomechanical modelling and clinical assessment data gathering with technological innovations towards movement restoration and sports performance for people with disabilities
Grantee:Claudiane Arakaki Fukuchi
Support Opportunities: Scholarships in Brazil - Post-Doctoral