Titanium-Based Alloy Surface Modification with TiO2 and Poly(sodium 4-styrenesulfonate) Multilayers for Dental Implants

Author(s)

Kitagawa, Igor L. ^{[1, 2]} ; Miyazaki, Celina M. ^[3] ; Pitol-Palin, Leticia ^[4] ; Okamoto, Roberta ^[4] ; de Vasconcellos, Luana M. R. ^[5] ; Constantino, Carlos J. L. ^[6] ; Lisboa-Filho, Paulo N. ^[1]

Affiliation

^[1] Sao Paulo State Univ, Sch Sci, Dept Phys, UNESP, BR-17033360 Bauru, SP - Brazil

^[2] IFSP Fed Inst Educ, Sci & Technol Sao Paulo, BR-16201407 Birigui, SP - Brazil

^[3] Univ Fed Sao Carlos, CCTS, BR-18052780 Sorocaba, SP - Brazil

^[4] Sao Paulo State Univ, UNESP, Aracatuba Dent Sch, Dept Basic Sci, BR-16018805 Aracatuba - Brazil

^[5] Sao Paulo State Univ, Dept Biosci & Oral Diag, Inst Sci & Technol, UNESP, BR-12245000 Sao Jose Dos Campos, SP - Brazil

^[6] Sao Paulo State Univ, Sch Technol & Appl Sci, Dept Phys, UNESP, BR-19060900 Presidente Prudente, SP - Brazil

• Document type: Journal article
• Source: ACS APPLIED BIO MATERIALS; v. 4, n. 4, p. 3055-3066, APR 19 2021.
• Web of Science Citations: 1

Abstract

Implant placement is an important repair method in dentistry and orthopedics. Increasing efforts have focused on optimizing the biocompatibility and osseointegration properties of titanium (Ti) and Ti-based alloys. In this work, Ti-based alloys were modified by the layer-by-layer (LbL) technique, which is a simple and versatile method for surface modification. The morphology and chemical structure of LbL films of poly(sodium 4-styrenesulfonate) (PSS) and Ti dioxide (TiO2) nanoparticles were first characterized employing ultraviolet-visible and Fouriertransform infrared spectroscopies as well as atomic force microscopy for further application in Ti-based alloy implants. The changes provoked by the LbL PSS/TiO2 film on the Ti-based alloy surfaces were then investigated by scanning electron microscopy and micro-Raman techniques. Finally, in vivo tests (immunolabeling and biomechanical analysis) performed with screw implants in rats suggested that PSS/TiO2 multilayers promote changes in both topography and chemical surface properties of the screw, providing beneficial effects for osteoblast activity. This simple and relatively low-cost growth process can open up possibilities to improve dental implants and, probably, bone implants in general. (AU)

• FAPESP's process: 14/15093-7 - Study of nanostructured systems by surface plasmon resonance (SPR): applications in biosensing
• Grantee: Celina Massumi Miyazaki
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 17/15035-5 - Adsorption of bisphosphonates and proteins on TiO2 surfaces for bone implants
• Grantee: Paulo Noronha Lisboa Filho
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/03114-0 - ASSOCIATION OF SYSTEMIC AND LOCAL MEDICAMENT TREATMENT DURING THE PERIMPLANTAR REPAIR PROCESS IN OVARIECTOMIZED RATS CARRIERS OF METABOLIC SYNDROME
• Grantee: Roberta Okamoto
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/07296-2 - CDMF - Center for the Development of Functional Materials
• Grantee: Elson Longo da Silva
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC