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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Parkin is downregulated among autophagy-related proteins prior to hyperphosphorylation of Tau in TS65DN mice

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Author(s):
Henrique, Alan M. [1] ; Gianetti, Nathalia G. [1] ; Ferrari, Merari F. R. [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Inst Biociencias, Dept Genet & Biol Evolut, Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Biochemical and Biophysical Research Communications; v. 561, p. 59-64, JUL 5 2021.
Web of Science Citations: 0
Abstract

Autophagy is a pathway through which cells execute a plethora of functions, such as macromolecules and organelles quality control, recycling of building blocks and apoptosis. Numerous studies have shown in the past that autophagy is an important mechanism associated with the pathology of various neurodegenerative diseases, whose impairment may lead to several disease-characteristic phenotypes (e.g. misfolded protein and defective organelles accumulation). With this in mind, we aimed to investigate whether alterations in expression of autophagy-related proteins would show before hyperphosphorylation of Tau, a hallmark of Alzheimer's disease (AD). After analyzing 7 different proteins, we observed that, while Pink1 and p62 show an age-related reduction in the Ts65Dn mice respectively in the locus coeruleus and hippocampus, Parkin shows an age-genotype interaction-associated reduction in both brain areas. This suggests potential outcomes in pathways associated with Parkin that could relate to later stages of the disease development. (c) 2021 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 13/08028-1 - CEGH-CEL - Human Genome and Stem Cell Research Center
Grantee:Mayana Zatz
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 18/11946-6 - Expression of proteins involved in mitophagy and retrograde traffic of autophagosomes prior and after protein aggregation associated with Alzheimer's Disease
Grantee:Alan Moreira Henrique
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 18/07592-4 - The role of quality control mechanisms in the loss of proteostasis in age-dependent neurodegenerative diseases
Grantee:Merari de Fátima Ramires Ferrari
Support type: Regular Research Grants