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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of protein malnutrition on hematopoietic regulatory activity of bone marrow mesenchymal stem cells

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Author(s):
Hastreiter, Araceli Aparecida [1] ; dos Santos, Guilherme G. [1] ; Makiyama, Edson Naoto [1] ; Santos, Ed Wilson Cavalcante [1] ; Borelli, Primavera [1] ; Fock, Ricardo Ambrosio [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: JOURNAL OF NUTRITIONAL BIOCHEMISTRY; v. 93, JUL 2021.
Web of Science Citations: 0
Abstract

Protein malnutrition causes anemia and leukopenia as it reduces hematopoietic precursors and impairs the production of mediators that regulate hematopoiesis. Hematopoiesis occurs in distinct bone marrow niches that modulate the processes of differentiation, proliferation and self-renewal of hematopoietic stem cells (HSCs). Mesenchymal stem cells (MSCs) contribute to the biochemical composition of bone marrow niches by the secretion of several growth factors and cytokines, and they play an important role in the regulation of HSCs and hematopoietic progenitors. In this study, we investigated the effect of protein malnutrition on the hematopoietic regulatory function of MSCs. C57BL/6NTaq mice were divided into control and protein malnutrition groups, which received, respectively, a normal protein diet (12% casein) and a low protein diet (2% casein). The results showed that protein malnutrition altered the synthesis of SCF, TFG-beta, Angpt-1, CXCL-12, and G-CSF by MSCs. Additionally, MSCs from the protein malnutrition group were not able to maintain the lymphoid, granulocytic and megakaryocytic-erythroid differentiation capacity compared to the MSCs of the control group. In this way, the comprehension of the role of MSCs on the regulation of the hematopoietic cells, in protein malnutrition states, is for the first time showed. Therefore, we infer that hematopoietic alterations caused by protein malnutrition are due to multifactorial alterations and, at least in part, the MSCs' contribution to hematological impairment. (C) 2021 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 18/25813-8 - Effect of protein malnutrition on hematopoiesis. marrow endothelial cell involvement and action of granulocytic colony stimulating factor (G-CSF)
Grantee:Ricardo Ambrósio Fock
Support Opportunities: Regular Research Grants
FAPESP's process: 14/06872-2 - Evaluation of hematopoietic regulatory aspects in protein malnutrition: the role of bone marrow endothelial-like cells derived from mesenchymal stem cells
Grantee:Ricardo Ambrósio Fock
Support Opportunities: Regular Research Grants