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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Toll-like Receptor 4 Signaling is Critical for the Adaptive Cellular Stress Response Effects Induced by Intermittent Fasting in the Mouse Brain

Full text
Author(s):
Vasconcelos, Andrea R. [1] ; da Paixao, Amanda G. [1] ; Kinoshita, Paula F. [1] ; Orellana, Ana M. [1] ; Scavone, Cristoforo [1] ; Kawamoto, Elisa M. [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, BR-05508900 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Neuroscience; v. 465, p. 142-153, JUN 15 2021.
Web of Science Citations: 0
Abstract

Among different kinds of dietary energy restriction, intermittent fasting (IF) has been considered a dietary regimen which causes a mild stress to the organism. IF can stimulate proteins and signaling pathways related to cell stress that can culminate in the increase of the body resistance to severe stress conditions. Energy intake reduction induced by IF can induce modulation of receptors, kinases, and phosphatases, which in turn can modulate the activation of transcription factors such as NF-E2-related factor 2 (NRF2) and cAMP response element binding (CREB) which regulate the transcription of genes related to the translation of proteins such as growth factors: brain-derived neurotrophic factor (BDNF), chaperone proteins: heat shock proteins (HSP), and so on. It has been shown that toll-like receptors (TLRs) are important molecules in innate immune response which are present not only in the periphery but also in neurons and glial cells. In central nervous system, TLRs can exert functions related to set up responses to infection, as well as influence neural progenitor cell proliferation and differentiation, being involved in cognitive parameters such as learning and memory. Little is known about the involvement of TLR4 on the beneficial effects induced by IF protocol. The present work investigated the effects of IF on memory and on the signaling mechanisms associated with NRF2 and CREB in Tlr4 knockout mice. The results suggest that TLR4 participates in the modulatory effects of IF on oxidative stress levels, on the transcription factors CREB and NRF2, and on BDNF and HSP90 expressions in hippocampus. (c) 2021 IBRO. Published by Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 14/01435-3 - The role of TNFR1 in the effects of ouabain in the inflammatory signaling in mice hippocampus
Grantee:Paula Fernanda Kinoshita
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 19/12974-6 - Evaluation of PTEN inhibition and compartmentalization effects in the presence of neuroinflammation: participation of glutamatergic signaling
Grantee:Elisa Mitiko Kawamoto Iwashe
Support Opportunities: Regular Research Grants
FAPESP's process: 16/22996-9 - Evaluation of physical exercise effects on cognition of neuronal-PTEN deleted animals
Grantee:Elisa Mitiko Kawamoto Iwashe
Support Opportunities: Regular Research Grants
FAPESP's process: 16/07376-4 - Evaluation of the effects of PTEN compartmentalization in human cells of glioblastoma (U87MG) submitted to a inflammatory stimuli
Grantee:Amanda Galvão da Paixão
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 06/57729-9 - Amyloid-beta (Abeta) peptide activates NF-kB through NMDA-Ras pathway in cerebellar primary cell culture
Grantee:Elisa Mitiko Kawamoto Iwashe
Support Opportunities: Research Grants - Meeting - Abroad
FAPESP's process: 16/07427-8 - Aging and neuroprotection: effects of Klotho protein in energetic metabolism, Na,K-ATPase signaling and adaptative response in central nervous system
Grantee:Cristoforo Scavone
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 11/12255-8 - Influence of TLR4 receptors in behavioral and neurochemical alterations caused by intermittent fasting in C3H/HeJ mice
Grantee:Andrea Rodrigues Vasconcelos
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 09/11915-4 - Behavioural and biochemical changes induced by calorie restriction in LPS signalling in central nervous system
Grantee:Andrea Rodrigues Vasconcelos
Support Opportunities: Scholarships in Brazil - Master