Immunohistochemical evaluation of Langerhans cells in oral lichen planus and oral lichenoid lesions

Author(s)

Ferrisse, Tulio Morandin ^[1] ; de Oliveira, Analu Barros ^[2] ; Palacon, Mariana Paravani ^[1] ; da Silveira, Heitor Albergoni ^[1] ; Sgavioli Massucato, Elaine Maria ^[1] ; de Almeida, Luciana Yamamoto ^[3] ; Leon, Jorge Esquiche ^[4] ; Bufalino, Andreia ^[1]

Affiliation

^[1] Sao Paulo State Univ Unesp, Sch Dent, Dept Diag & Surg, Oral Med, Araraquara, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Sch Dent, Dept Orthodont & Pediat Dent, Araraquara, SP - Brazil

^[3] Univ Sao Paulo, Dept Pathol & Forens Med, Ribeirao Preto Med Scholl FMRP USP, Ribeirao Preto - Brazil

^[4] Univ Sao Paulo, Ribeirao Preto Dent Sch FORP USP, Dept Stomatol Publ Oral Hlth & Forens Dent, Oral Pathol, Ave Cafe S-N, BR-14040904 Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: ARCHIVES OF ORAL BIOLOGY; v. 124, APR 2021.
• Web of Science Citations: 0

Abstract

Objective: the aim of this study was to evaluate the density of Langerhans cells in oral lichen planus (OLP) and oral lichenoid lesions (OLL). Design: 14 cases of OLP, 15 cases of OLL and 14 cases of oral inflammatory fibrous hyperplasia (OIFH), were selected for immunohistochemical analysis of CD1a, CD207 and S100 expression. The OIFH group was subdivided according to the presence (OIFHL n = 14) or absence (OIFHNL n = 14) of lichenoid inflammatory infiltrate. Positive cells were counted in intraepithelial and subepithelial areas. Results were analyzed by multivariate comparative analysis, correlation analysis, linear regression models and Student's T-test. Results: A significantly higher amount of CD207+ cells in OLL vs OLP was observed (p = 0.015). The prevailing reticular pattern observed was CD207(high) for OLP (p = 0.0329). A statistically significant difference in the expression of CD1a and CD207 was observed for intraepithelial vs subepithelial areas (p = 0.024 and p=0.015, for CD1a and CD207, respectively). Significant correlations were also observed between the expression of CD1a + and CD207+ cells in the pathogenesis of OLP and OLL. Conclusion: High levels of CD207+cells in OLP compared with OLL may help explain the differences in the immunopathogenesis of both diseases. Additionally, CD1a + and CD207+ cells appear to be more essential to immunopathogenesis of OLL than to the pathogenesis of OLP. (AU)

• FAPESP's process: 16/11419-0 - Clinicopathological correlation of the degree of differentiation, tetraspanin expression, viral agents and cell proliferation in a large sample of squamous cell carcinoma of the head and neck region.
• Grantee: Jorge Esquiche León
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/01438-0 - The role of the innate and adaptive immune responses in oral leukoplakia and oral proliferative verrucous leukoplakia
• Grantee: Andreia Bufalino
• Support Opportunities: Regular Research Grants