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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Occurrence of multidrug-resistant Enterococcus faecium isolated from environmental samples

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Author(s):
dos Santos, L. D. R. [1] ; Furlan, J. P. R. [1] ; Gallo, I. F. L. [1] ; Ramos, M. S. [1] ; Savazzi, E. A. [2] ; Stehling, E. G. [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Dept Anal Clin Toxicol & Bromatol, Fac Ciencias Farmaceut Ribeirao Preto, Sao Paulo - Brazil
[2] Companhia Ambiental Estado Sao Paulo CETESB, Ribeirao Preto - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Letters in Applied Microbiology; v. 73, n. 2, p. 237-246, AUG 2021.
Web of Science Citations: 0
Abstract

Enterococcus species are present in the microbiota of humans and animals and have also been described in the environment. Among the species, Enterococcus faecium is one of the main pathogens associated with nosocomial infections worldwide. Enterococcus faecium isolates resistant to different classes of antimicrobials have been increasingly reported, including multidrug-resistant (MDR) isolates in environmental sources, which is worrying. Therefore, this study aimed to characterize E. faecium isolates obtained from soil and water samples regarding antimicrobial resistance and virulence determinants. A total 40 E. faecium isolates were recovered from 171 environmental samples. All isolates were classified as MDR, highlighting the resistance to the fluoroquinolones class, linezolid and vancomycin. Furthermore, high-level aminoglycoside resistance and high-level ciprofloxacin resistance were detected in some isolates. Several clinically relevant antimicrobial resistance genes were found, including vanC1, ermB, ermC, mefAE, tetM, tetL, ant(6 `)-Ia, ant(4 `)-Ia, aph(3 `)-IIIa and aac(6 `)-Ie-aph(2 `')-Ia. Three virulence genes were detected among the MDR E. faecium isolates, such as esp, gelE and ace. The results of this study contribute to a better understanding of MDR E. faecium isolates carrying antimicrobial resistance and virulence genes in environmental sources and report for the first time in the world the presence of vanC1-producing E. faecium isolated from soil. (AU)

FAPESP's process: 18/01890-3 - Study of resistance, virulence and epidemiological profile of Escherichia coli isolated from environment
Grantee:João Pedro Rueda Furlan
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 18/19539-0 - Molecular characterization of Escherichia coli isolates from the environment
Grantee:Eliana Guedes Stehling
Support Opportunities: Regular Research Grants