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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Gene signatures of autopsy lungs from obese patients with COVID-19

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Author(s):
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Santos e Silva, Juan Carlo [1] ; Vasconcelos, Amanda Pereira [1] ; Yonehara Noma, Isabella Harumi [1] ; Noronha, Natalia Yumi [2] ; Aquino, Rodrigo [1] ; Giddaluru, Jeevan [1, 3] ; Durao, Luiz [1] ; Costa-Martins, Andre Guilherme [1, 3] ; Schuch, Viviane [1] ; Moraes-Vieira, Pedro M. [4, 5] ; Nakaya, I, Helder
Total Authors: 11
Affiliation:
[1] I, Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Sao Paulo - Brazil
[3] I, Univ Sao Paulo, Sci Platform Pasteur, Sao Paulo - Brazil
[4] Univ Estadual Campinas, Obes & Comorbid Res Ctr OCRC, Campinas, SP - Brazil
[5] Univ Estadual Campinas, Inst Biol, Dept Genet Evolut Microbiol & Immunol, Lab Immunometab, Campinas - Brazil
Total Affiliations: 5
Document type: Journal article
Source: CLINICAL NUTRITION ESPEN; v. 44, p. 475-478, AUG 2021.
Web of Science Citations: 0
Abstract

Background \& aims: Obesity is associated with low grade systemic inflammation and insulin resistance. Although metabolic and immunological changes may contribute to the increased risk for COVID-19 mortality in obese, little is known about the impact of obesity in the lungs of patients with COVID-19. Methods: We analyzed gene expression profiles of autopsy lungs of a cohort of 14 COVID-19 patients and 4 control individuals. Patients were divided into 3 groups according to their comorbidities: hypertension, type 2 diabetes (T2D) and obesity. We then identified the molecular alterations associated with these comorbidities in COVID-19 patients. Results: Patients with only hypertension showed higher levels of inflammatory genes and B-cell related genes when compared to those with T2D and obesity. However, the levels of IFN-gamma, IL22, and CD274 (a ligand that binds to receptor PD1) were higher in COVID-19 patients with T2D and obesity. Several metabolic- and immune-associated genes such as G6PD, LCK and IL10 were significantly induced in the lungs of the obese group. Conclusion: Our findings suggest that SARS-CoV-2 infection in the lungs may exacerbate the immune response and chronic condition in obese COVID-19 patients. (C) 2021 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 19/27139-5 - Application of genomic tools for the study of epidemiological databases
Grantee:Juan Carlo Santos e Silva
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 18/14933-2 - Integrative biology applied to human health
Grantee:Helder Takashi Imoto Nakaya
Support type: Research Grants - Young Investigators Grants - Phase 2
FAPESP's process: 20/04579-7 - Study of the risk factors associated with greater severity to COVID-19 and mapping of the metabolic pathways required for the anti-SARS-CoV-2 response
Grantee:Pedro Manoel Mendes de Moraes Vieira
Support type: Regular Research Grants
FAPESP's process: 19/27146-1 - Integration of transcriptome data with clinical and immunological data
Grantee:Amanda Pereira Vasconcelos
Support type: Scholarships in Brazil - Doctorate (Direct)