| Full text | |
| Author(s): Show less - |
Santos e Silva, Juan Carlo
[1]
;
Vasconcelos, Amanda Pereira
[1]
;
Yonehara Noma, Isabella Harumi
[1]
;
Noronha, Natalia Yumi
[2]
;
Aquino, Rodrigo
[1]
;
Giddaluru, Jeevan
[1, 3]
;
Durao, Luiz
[1]
;
Costa-Martins, Andre Guilherme
[1, 3]
;
Schuch, Viviane
[1]
;
Moraes-Vieira, Pedro M.
[4, 5]
;
Nakaya, I, Helder
Total Authors: 11
|
| Affiliation: | [1] I, Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Sao Paulo - Brazil
[3] I, Univ Sao Paulo, Sci Platform Pasteur, Sao Paulo - Brazil
[4] Univ Estadual Campinas, Obes & Comorbid Res Ctr OCRC, Campinas, SP - Brazil
[5] Univ Estadual Campinas, Inst Biol, Dept Genet Evolut Microbiol & Immunol, Lab Immunometab, Campinas - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | CLINICAL NUTRITION ESPEN; v. 44, p. 475-478, AUG 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Background \& aims: Obesity is associated with low grade systemic inflammation and insulin resistance. Although metabolic and immunological changes may contribute to the increased risk for COVID-19 mortality in obese, little is known about the impact of obesity in the lungs of patients with COVID-19. Methods: We analyzed gene expression profiles of autopsy lungs of a cohort of 14 COVID-19 patients and 4 control individuals. Patients were divided into 3 groups according to their comorbidities: hypertension, type 2 diabetes (T2D) and obesity. We then identified the molecular alterations associated with these comorbidities in COVID-19 patients. Results: Patients with only hypertension showed higher levels of inflammatory genes and B-cell related genes when compared to those with T2D and obesity. However, the levels of IFN-gamma, IL22, and CD274 (a ligand that binds to receptor PD1) were higher in COVID-19 patients with T2D and obesity. Several metabolic- and immune-associated genes such as G6PD, LCK and IL10 were significantly induced in the lungs of the obese group. Conclusion: Our findings suggest that SARS-CoV-2 infection in the lungs may exacerbate the immune response and chronic condition in obese COVID-19 patients. (C) 2021 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 19/27139-5 - Application of genomic tools for the study of epidemiological databases |
| Grantee: | Juan Carlo Santos e Silva |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 18/14933-2 - Integrative biology applied to human health |
| Grantee: | Helder Takashi Imoto Nakaya |
| Support Opportunities: | Research Grants - Young Investigators Grants - Phase 2 |
| FAPESP's process: | 20/04579-7 - Study of the risk factors associated with greater severity to COVID-19 and mapping of the metabolic pathways required for the anti-SARS-CoV-2 response |
| Grantee: | Pedro Manoel Mendes de Moraes Vieira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 19/27146-1 - Integration of transcriptome data with clinical and immunological data |
| Grantee: | Amanda Pereira Vasconcelos |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |