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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Association between DNA ploidy and micronucleus frequency in chronic smokers and impact of smoking cessation

Full text
Author(s):
Cruz, B. S. [1] ; Schwarzmeier, L. A. T. [1] ; Carvalho, B. F. D. C. [1] ; Alves, M. G. O. [2, 1, 3] ; Carta, C. F. L. [1] ; Balducci, I [4] ; Scholz, J. R. [5] ; Almeida, J. D. [1]
Total Authors: 8
Affiliation:
[1] Sao Paulo State Univ Unesp, Inst Sci & Technol, Dept Biosci & Oral Diag, 777 Av Eng Francisco Jose Longo, BR-12245000 Sao Jose Dos Campos, SP - Brazil
[2] Univ Mogi das Cruzes, Mogi Das Cruzes, SP - Brazil
[3] Univ Anhembi Morumbi, Sao Jose Dos Campos, SP - Brazil
[4] Sao Paulo State Univ Unesp, Inst Sci & Technol, Dept Social Sci & Pediat Dent, Sao Jose Dos Campos, SP - Brazil
[5] Univ Sao Paulo, Med Sch, Univ Hosp, Heart Inst, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Review article
Source: HUMAN & EXPERIMENTAL TOXICOLOGY; v. 40, n. 8, p. 1374-1382, AUG 2021.
Web of Science Citations: 1
Abstract

Tobacco use may initiate the process of oral carcinogenesis with clinically undetectable changes. Smoking cessation may prevent its progression. The objective of this study was to evaluate the association between DNA ploidy and micronucleus (MN) frequency in chronic smokers. Three groups were evaluated: Smoker Group, Former Smoker Group and Control Group. Exfoliative cytology was performed on the lateral border of the tongue and mouth floor. MN and DNA ploidy analyses were performed, as well as the correlation between the variables. The data showed a difference between the groups for the total MN (p = 0.0227), and the Smoker group had the highest mean (4.22 +/- 4.12). The three groups did not differ statistically from each other on ploidy evaluation (p-value > 0.05). There was also an association between aneuploidy and increased MN frequency in the Former Smoker group (p = 0.0036). In conclusion, these results point out that there is a relationship between the frequency of MN and aneuploidy in former smokers. Moreover, smoking cessation, even for a short period of time, may promote the decrease of MN frequency caused by tobacco use. (AU)

FAPESP's process: 16/24047-4 - Association of DNA ploidia and the frequency of micronucle in oral mucosa in chronic smoking patients
Grantee:Beatriz Serralheiro da Cruz
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 13/09910-0 - Effect of chronic smoking and abstinence on aneuploidy in oral mucosa cells
Grantee:Bruna Fernandes do Carmo Carvalho
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/05371-4 - Cytogenetic evaluation of smoking damage in oral mucosa
Grantee:Janete Dias Almeida
Support Opportunities: Regular Research Grants